Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI024157-04S1
Application #
3136907
Study Section
Immunobiology Study Section (IMB)
Project Start
1987-04-01
Project End
1993-03-31
Budget Start
1991-01-01
Budget End
1991-03-31
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Milam, Ashley A Viehmann; Bartleson, Juliet M; Donermeyer, David L et al. (2018) Tuning T Cell Signaling Sensitivity Alters the Behavior of CD4+ T Cells during an Immune Response. J Immunol 200:3429-3437
Ransdell, Joseph L; Dranoff, Edward; Lau, Brandon et al. (2017) Loss of Nav?4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance. Cell Rep 19:532-544
Viehmann Milam, Ashley A; Allen, Paul M (2017) The TCR Takes Some Immune Responsibility. Immunity 47:803-804
Hong, Jinsung; Persaud, Stephen P; Horvath, Stephen et al. (2015) Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells. J Immunol 195:3557-64
Rodriguez, Stephanie N; Jiang, Meizi; Bujo, Hideaki et al. (2015) Self-pMHCII complexes are variably expressed in the thymus and periphery independent of mRNA expression but dependent on the activation state of the APCs. Mol Immunol 63:428-36
Klein, Ludger; Kyewski, Bruno; Allen, Paul M et al. (2014) Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nat Rev Immunol 14:377-91
Ni, Peggy P; Solomon, Benjamin; Hsieh, Chyi-Song et al. (2014) The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires. J Immunol 193:1778-86
Persaud, Stephen P; Parker, Chelsea R; Lo, Wan-Lin et al. (2014) Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat Immunol 15:266-74
Chou, Chun; Pinto, Amelia K; Curtis, Jonathan D et al. (2014) c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells. Nat Immunol 15:884-93
Ni, Peggy P; Wang, Yaming; Allen, Paul M (2014) Both positive and negative effects on immune responses by expression of a second class II MHC molecule. Mol Immunol 62:199-208

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