Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI024465-01
Application #
3137476
Study Section
Immunobiology Study Section (IMB)
Project Start
1987-04-01
Project End
1990-03-31
Budget Start
1987-04-01
Budget End
1988-03-31
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Brandeis University
Department
Type
Schools of Arts and Sciences
DUNS #
616845814
City
Waltham
State
MA
Country
United States
Zip Code
02454
Han, Jin-Hwan; Umiker, Benjamin R; Kazimirova, Anastasia A et al. (2014) Expression of an anti-RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN-I expression. Eur J Immunol 44:215-26
Balter, Barbara B; Ciccone, David N; Oettinger, Marjorie A et al. (2012) Mice lacking Sýý tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations. Mol Immunol 52:1-8
Shansab, Maryam; Eccleston, Jennifer M; Selsing, Erik (2011) Translocation of an antibody transgene requires AID and occurs by interchromosomal switching to all switch regions except the mu switch region. Eur J Immunol 41:1456-64
Shansab, Maryam; Selsing, Erik (2011) p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation. Mol Immunol 48:973-8
Eccleston, Jennifer; Yan, Catherine; Yuan, Karen et al. (2011) Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining. J Immunol 186:2336-43
Eccleston, Jennifer; Schrader, Carol E; Yuan, Karen et al. (2009) Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats. J Immunol 183:1222-8
Han, Jin-Hwan; Akira, Shizuo; Calame, Kathryn et al. (2007) Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. Immunity 27:64-75
Wuerffel, Robert; Wang, Lili; Grigera, Fernando et al. (2007) S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity 27:711-22
Selsing, Erik (2006) Ig class switching: targeting the recombinational mechanism. Curr Opin Immunol 18:249-54
Min, Irene M; Rothlein, Lisa R; Schrader, Carol E et al. (2005) Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2. J Exp Med 201:1885-90

Showing the most recent 10 out of 22 publications