Molecular Genetic Analysis of Shigella Pathogenicity

Maurelli, Anthony T.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI024656-08
• Application #: 2062669
• Study Section: Bacteriology and Mycology Subcommittee 2 (BM)
• Project Start: 1988-12-01
• Project End: 1997-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 8
• Fiscal Year: 1996

Institution

• Name: Henry M. Jackson Fdn for the Adv Mil/Med
• City: Rockville
• State: MD
• Country: United States
• Zip Code: 20817

Publications

Fogolari, Marta; Mavian, Carla; Angeletti, Silvia et al. (2018) Distribution and characterization of Shiga toxin converting temperate phages carried by Shigella flexneri in Hispaniola. Infect Genet Evol 65:321-328

Lampel, Keith A; Formal, Samuel B; Maurelli, Anthony T (2018) A Brief History of Shigella. EcoSal Plus 8:

Bliven, Kimberly A; Maurelli, Anthony T (2016) Evolution of Bacterial Pathogens Within the Human Host. Microbiol Spectr 4:

Gray, M D; Lacher, D W; Leonard, S R et al. (2015) Prevalence of Shiga toxin-producing Shigella species isolated from French travellers returning from the Caribbean: an emerging pathogen with international implications. Clin Microbiol Infect 21:765.e9-765.e14

Gray, Miranda D; Lampel, Keith A; Strockbine, Nancy A et al. (2014) Clinical isolates of Shiga toxin 1a-producing Shigella flexneri with an epidemiological link to recent travel to Hispañiola. Emerg Infect Dis 20:1669-77

Emanuele, Anthony A; Adams, Nancy E; Chen, Yi-Chen et al. (2014) Potential novel antibiotics from HTS targeting the virulence-regulating transcription factor, VirF, from Shigella flexneri. J Antibiot (Tokyo) 67:379-86

Bliven, Kimberly A; Maurelli, Anthony T (2012) Antivirulence genes: insights into pathogen evolution through gene loss. Infect Immun 80:4061-70

Faherty, Christina S; Merrell, D Scott; Semino-Mora, Cristina et al. (2010) Microarray analysis of Shigella flexneri-infected epithelial cells identifies host factors important for apoptosis inhibition. BMC Genomics 11:272

Zurawski, Daniel V; Mumy, Karen L; Faherty, Christina S et al. (2009) Shigella flexneri type III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma protein. Mol Microbiol 71:350-68

Faherty, Christina S; Maurelli, Anthony T (2009) Spa15 of Shigella flexneri is secreted through the type III secretion system and prevents staurosporine-induced apoptosis. Infect Immun 77:5281-90