Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI026251-07
Application #
2063299
Study Section
Experimental Virology Study Section (EVR)
Project Start
1990-01-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Moser, C A; Offit, P A (2001) Distribution of rotavirus-specific memory B cells in gut-associated lymphoid tissue after primary immunization. J Gen Virol 82:2271-4
Macartney, K K; Baumgart, D C; Carding, S R et al. (2000) Primary murine small intestinal epithelial cells, maintained in long-term culture, are susceptible to rotavirus infection. J Virol 74:5597-603
Brubaker, J O; Patil, R T; Speaker, T J et al. (2000) A quantitative luminescence assay for measuring cell uptake of aqueous-based microcapsules in vitro. J Immunol Methods 237:85-93
Coffin, S E; Clark, S L; Bos, N A et al. (1999) Migration of antigen-presenting B cells from peripheral to mucosal lymphoid tissues may induce intestinal antigen-specific IgA following parenteral immunization. J Immunol 163:3064-70
Moser, C A; Speaker, T J; Offit, P A (1998) Effect of water-based microencapsulation on protection against EDIM rotavirus challenge in mice. J Virol 72:3859-62
Brown, K A; Offit, P A (1998) Rotavirus-specific proteins are detected in murine macrophages in both intestinal and extraintestinal lymphoid tissues. Microb Pathog 24:327-31
Moser, C A; Cookinham, S; Coffin, S E et al. (1998) Relative importance of rotavirus-specific effector and memory B cells in protection against challenge. J Virol 72:1108-14
Coffin, S E; Offit, P A (1998) Induction of mucosal B-cell memory by intramuscular inoculation of mice with rotavirus. J Virol 72:3479-83
Coffin, S E; Moser, C A; Cohen, S et al. (1997) Immunologic correlates of protection against rotavirus challenge after intramuscular immunization of mice. J Virol 71:7851-6
Moser, C A; Speaker, T J; Offit, P A (1997) Effect of microencapsulation on immunogenicity of a bovine herpes virus glycoprotein and inactivated influenza virus in mice. Vaccine 15:1767-72

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