Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI026833-09
Application #
2063576
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1988-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1998-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Tennessee Health Science Center
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163
Marion, Tony N; Postlethwaite, Arnold E (2014) Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus. Semin Immunopathol 36:495-517
Radic, Marko; Marion, Tony N (2013) Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity. Semin Immunopathol 35:465-80
Krishnan, Meera R; Wang, Congmiao; Marion, Tony N (2012) Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice. Kidney Int 82:184-92
Steeves, Meredith A; Marion, Tony N (2004) Tolerance to DNA in (NZB x NZW)F1 mice that inherit an anti-DNA V(H) as a conventional micro H chain transgene but not as a V(H) knock-in transgene. J Immunol 172:6568-77
Marion, Tony N; Krishnan, Meera R; Steeves, Meredith A et al. (2003) Affinity maturation and autoimmunity to DNA. Curr Dir Autoimmun 6:123-53
Desai, D D; Marion, T N (2000) Induction of anti-DNA antibody with DNA-peptide complexes. Int Immunol 12:1569-78
Krishnan, M R; Marion, T N (1998) Comparison of the frequencies of arginines in heavy chain CDR3 of antibodies expressed in the primary B-cell repertoires of autoimmune-prone and normal mice. Scand J Immunol 48:223-32
Ash-Lerner, A; Ginsberg-Strauss, M; Pewzner-Jung, Y et al. (1997) Expression of an anti-DNA-associated VH gene in immunized and autoimmune mice. J Immunol 159:1508-19
Marion, T N; Krishnan, M R; Desai, D D et al. (1997) Monoclonal anti-DNA antibodies: structure, specificity, and biology. Methods 11:3-11
Krishnan, M R; Jou, N T; Marion, T N (1996) Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies. J Immunol 157:2430-9

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