Abstract

Long=term objectives are to reduce morbidity and mortality due to congenital Toxoplasma gondii infection by improved use of antimicrobial agents and understanding its pathogenesis.
Our specific aim i s to determine optimal methods to evaluate, treat and provide follow up care for children suffering from congenital toxoplasmosis. Our ongoing, prospective, randomized treatment trial will be continued, as initially planned, to determine early and long term outcome for treated children, including children who have been treated in utero. Cognitive, motor, ocular and audiologic outcome will be determined following treatment with one of two dosages of pyrimethamine plus sulfadiazine during the first year of life. Evaluation of the cohort of older, untreated """"""""historical patient"""""""" children with retinal disease provides an ideal and well characterized group of patients for a future randomized, placebo-controlled study of effect of antimicrobial agents active against encysted bradyzoites on relapsing chorioretinitis. These studies will contribute to determining how to best provide medical care to children afflicted with congenital toxoplasmosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI027530-14
Application #
6373152
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Program Officer
Gottlieb, Michael
Project Start
1994-09-01
Project End
2005-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
14
Fiscal Year
2001
Total Cost
$403,208
Indirect Cost

  Institution

Name
University of Chicago
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Lykins, Joseph; Li, Xuan; Levigne, Pauline et al. (2018) Rapid, inexpensive, fingerstick, whole-blood, sensitive, specific, point-of-care test for anti-Toxoplasma antibodies. PLoS Negl Trop Dis 12:e0006536
Ngô, Huân M; Zhou, Ying; Lorenzi, Hernan et al. (2017) Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer. Sci Rep 7:11496
Lykins, Joseph; Wang, Kanix; Wheeler, Kelsey et al. (2016) Understanding Toxoplasmosis in the United States Through ""Large Data"" Analyses. Clin Infect Dis 63:468-75
Hutson, Samuel L; Wheeler, Kelsey M; McLone, David et al. (2015) Patterns of Hydrocephalus Caused by Congenital Toxoplasma gondii Infection Associate With Parasite Genetics. Clin Infect Dis 61:1831-4
Contopoulos-Ioannidis, Despina; Wheeler, Kelsey M; Ramirez, Raymund et al. (2015) Clustering of Toxoplasma gondii Infections Within Families of Congenitally Infected Infants. Clin Infect Dis 61:1815-24
El Bissati, Kamal; Zhou, Ying; Dasgupta, Debleena et al. (2014) Effectiveness of a novel immunogenic nanoparticle platform for Toxoplasma peptide vaccine in HLA transgenic mice. Vaccine 32:3243-8
Witola, William H; Liu, Susan Ruosu; Montpetit, Alexandre et al. (2014) ALOX12 in human toxoplasmosis. Infect Immun 82:2670-9
Bela, Samantha R; Dutra, Miriam S; Mui, Ernest et al. (2012) Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii. Infect Immun 80:4298-308
Burrowes, Delilah; Boyer, Kenneth; Swisher, Charles N et al. (2012) Spinal Cord Lesions in Congenital Toxoplasmosis Demonstrated with Neuroimaging, Including Their Successful Treatment in an Adult. J Neuroparasitology 3:
McLeod, Rima; Boyer, Kenneth M; Lee, Daniel et al. (2012) Prematurity and severity are associated with Toxoplasma gondii alleles (NCCCTS, 1981-2009). Clin Infect Dis 54:1595-605

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