Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI028457-08S1
Application #
2549435
Study Section
Special Emphasis Panel (ZAI1-GSM-M (O1))
Project Start
1989-07-01
Project End
2000-07-31
Budget Start
1997-08-01
Budget End
1998-07-31
Support Year
8
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Larson, Thomas R; Yother, Janet (2017) Streptococcus pneumoniae capsular polysaccharide is linked to peptidoglycan via a direct glycosidic bond to ?-D-N-acetylglucosamine. Proc Natl Acad Sci U S A 114:5695-5700
Geno, K Aaron; Hauser, Jocelyn R; Gupta, Kanupriya et al. (2014) Streptococcus pneumoniae phosphotyrosine phosphatase CpsB and alterations in capsule production resulting from changes in oxygen availability. J Bacteriol 196:1992-2003
Oliver, Melissa B; Jones, Chris; Larson, Thomas R et al. (2013) Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units. J Biol Chem 288:21945-54
James, David B A; Gupta, Kanupriya; Hauser, Jocelyn R et al. (2013) Biochemical activities of Streptococcus pneumoniae serotype 2 capsular glycosyltransferases and significance of suppressor mutations affecting the initiating glycosyltransferase Cps2E. J Bacteriol 195:5469-78
James, David B A; Yother, Janet (2012) Genetic and biochemical characterizations of enzymes involved in Streptococcus pneumoniae serotype 2 capsule synthesis demonstrate that Cps2T (WchF) catalyzes the committed step by addition of ?1-4 rhamnose, the second sugar residue in the repeat unit. J Bacteriol 194:6479-89
Calix, Juan J; Porambo, Richard J; Brady, Allison M et al. (2012) Biochemical, genetic, and serological characterization of two capsule subtypes among Streptococcus pneumoniae Serotype 20 strains: discovery of a new pneumococcal serotype. J Biol Chem 287:27885-94
Yother, Janet (2011) Capsules of Streptococcus pneumoniae and other bacteria: paradigms for polysaccharide biosynthesis and regulation. Annu Rev Microbiol 65:563-81
Kaufman, Greer E; Yother, Janet (2007) CcpA-dependent and -independent control of beta-galactosidase expression in Streptococcus pneumoniae occurs via regulation of an upstream phosphotransferase system-encoding operon. J Bacteriol 189:5183-92
Xayarath, Bobbi; Yother, Janet (2007) Mutations blocking side chain assembly, polymerization, or transport of a Wzy-dependent Streptococcus pneumoniae capsule are lethal in the absence of suppressor mutations and can affect polymer transfer to the cell wall. J Bacteriol 189:3369-81
Ventura, Christy L; Cartee, Robert T; Forsee, W Thomas et al. (2006) Control of capsular polysaccharide chain length by UDP-sugar substrate concentrations in Streptococcus pneumoniae. Mol Microbiol 61:723-33

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