Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI028797-04
Application #
2064624
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1992-07-01
Project End
1997-04-30
Budget Start
1995-05-01
Budget End
1997-04-30
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Kashyap, Des R; Kuzma, Marcin; Kowalczyk, Dominik A et al. (2017) Bactericidal peptidoglycan recognition protein induces oxidative stress in Escherichia coli through a block in respiratory chain and increase in central carbon catabolism. Mol Microbiol 105:755-776
Dziarski, Roman; Park, Shin Yong; Kashyap, Des Raj et al. (2016) Pglyrp-Regulated Gut Microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii Enhance and Alistipes finegoldii Attenuates Colitis in Mice. PLoS One 11:e0146162
Jing, Xuefang; Zulfiqar, Fareeha; Park, Shin Yong et al. (2014) Peptidoglycan recognition protein 3 and Nod2 synergistically protect mice from dextran sodium sulfate-induced colitis. J Immunol 193:3055-69
Kashyap, Des Raj; Rompca, Annemarie; Gaballa, Ahmed et al. (2014) Peptidoglycan recognition proteins kill bacteria by inducing oxidative, thiol, and metal stress. PLoS Pathog 10:e1004280
Park, Shin Yong; Jing, Xuefang; Gupta, Dipika et al. (2013) Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses. J Immunol 190:3480-92
Dziarski, Roman; Kashyap, Des Raj; Gupta, Dipika (2012) Mammalian peptidoglycan recognition proteins kill bacteria by activating two-component systems and modulate microbiome and inflammation. Microb Drug Resist 18:280-5
Park, Shin Yong; Gupta, Dipika; Hurwich, Risa et al. (2011) Peptidoglycan recognition protein Pglyrp2 protects mice from psoriasis-like skin inflammation by promoting regulatory T cells and limiting Th17 responses. J Immunol 187:5813-23
Kashyap, Des Raj; Wang, Minhui; Liu, Li-Hui et al. (2011) Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems. Nat Med 17:676-83
Park, Shin Yong; Gupta, Dipika; Kim, Chang H et al. (2011) Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells. PLoS One 6:e24961
Saha, Sukumar; Jing, Xuefang; Park, Shin Yong et al. (2010) Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-gamma. Cell Host Microbe 8:147-62

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