Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI028798-07
Application #
2064629
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1989-12-01
Project End
1999-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Shi, Huafang; Butler, Kiantra; Tschudi, Christian (2018) A single-point mutation in the RNA-binding protein 6 generates Trypanosoma brucei metacyclics that are able to progress to bloodstream forms in vitro. Mol Biochem Parasitol 224:50-56
Kolev, Nikolay G; Ramsdell, Trisha K; Tschudi, Christian (2018) Temperature shift activates bloodstream VSG expression site promoters in Trypanosoma brucei. Mol Biochem Parasitol 226:20-23
Shi, Huafang; Butler, Kiantra; Tschudi, Christian (2018) Differential expression analysis of transcriptome data of Trypanosoma brucei RBP6 induction in procyclics leading to infectious metacyclics and bloodstream forms in vitro. Data Brief 20:978-980
Srivastava, Ankita; Badjatia, Nitika; Lee, Ju Huck et al. (2018) An RNA polymerase II-associated TFIIF-like complex is indispensable for SL RNA gene transcription in Trypanosoma brucei. Nucleic Acids Res 46:1695-1709
Damasceno, Jeziel D; Silva, Gabriel LA; Tschudi, Christian et al. (2017) Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids. Mem Inst Oswaldo Cruz 112:572-576
Kolev, Nikolay G; Günzl, Arthur; Tschudi, Christian (2017) Metacyclic VSG expression site promoters are recognized by the same general transcription factor that is required for RNA polymerase I transcription of bloodstream expression sites. Mol Biochem Parasitol 216:52-55
Christiano, Romain; Kolev, Nikolay G; Shi, Huafang et al. (2017) The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion. Mol Microbiol 106:74-92
Alves e Silva, Thiago Luiz; Savage, Amy F; Aksoy, Serap (2016) Transcript Abundance of Putative Lipid Phosphate Phosphatases During Development of Trypanosoma brucei in the Tsetse Fly. Am J Trop Med Hyg 94:890-3
Savage, Amy F; Kolev, Nikolay G; Franklin, Joseph B et al. (2016) Transcriptome Profiling of Trypanosoma brucei Development in the Tsetse Fly Vector Glossina morsitans. PLoS One 11:e0168877
Ramey-Butler, Kiantra; Ullu, Elisabetta; Kolev, Nikolay G et al. (2015) Synchronous expression of individual metacyclic variant surface glycoprotein genes in Trypanosoma brucei. Mol Biochem Parasitol 200:1-4

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