Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI028900-07
Application #
2064719
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1990-01-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
New York University
Department
Pathology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
Genini, Davide; Brambilla, Lara; Laurini, Erik et al. (2017) Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells. Proc Natl Acad Sci U S A 114:E4924-E4933
Garama, Daniel J; Harris, Tiffany J; White, Christine L et al. (2015) A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3. Mol Cell Biol 35:3646-56
Gough, Daniel J; MariƩ, Isabelle J; Lobry, Camille et al. (2014) STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation. Blood 124:2252-61
Gnatovskiy, Leonid; Mita, Paolo; Levy, David E (2013) The human RVB complex is required for efficient transcription of type I interferon-stimulated genes. Mol Cell Biol 33:3817-25
Gough, Daniel J; Koetz, Lisa; Levy, David E (2013) The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation. PLoS One 8:e83395
Gough, Daniel J; Messina, Nicole L; Clarke, Christopher J P et al. (2012) Constitutive type I interferon modulates homeostatic balance through tonic signaling. Immunity 36:166-74
Levy, David E; MariƩ, Isabelle J (2012) STATus report on tetramers. Immunity 36:553-5
Lee, Jason E; Yang, Yang-Ming; Liang, Feng-Xia et al. (2012) Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function. Am J Physiol Cell Physiol 302:C804-20
Zhang, Liang; Das, Priyabrata; Schmolke, Mirco et al. (2012) Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export. J Cell Biol 196:315-26
Corcoran, Ryan B; Contino, Gianmarco; Deshpande, Vikram et al. (2011) STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. Cancer Res 71:5020-9

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