Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI029802-01
Application #
3815038
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037
Lehar, Sophie M; Bevan, Michael J (2006) T cells develop normally in the absence of both Deltex1 and Deltex2. Mol Cell Biol 26:7358-71
Lehar, Sophie M; Dooley, James; Farr, Andrew G et al. (2005) Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors. Blood 105:1440-7
Yun, Theodore J; Bevan, Michael J (2003) Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development. J Immunol 170:5834-41
Huang, Eugene Y; Gallegos, Alena M; Richards, Sabrina M et al. (2003) Surface expression of Notch1 on thymocytes: correlation with the double-negative to double-positive transition. J Immunol 171:2296-304
Krebs, L T; Deftos, M L; Bevan, M J et al. (2001) The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway. Dev Biol 238:110-9
Goldrath, A W; Bogatzki, L Y; Bevan, M J (2000) Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J Exp Med 192:557-64
Deftos, M L; Huang, E; Ojala, E W et al. (2000) Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity 13:73-84
Kirchner, J; Bevan, M J (1999) ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes. J Exp Med 190:217-28
Goldrath, A W; Bevan, M J (1999) Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity 11:183-90
Deftos, M L; He, Y W; Ojala, E W et al. (1998) Correlating notch signaling with thymocyte maturation. Immunity 9:777-86

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