Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI030084-05
Application #
2065441
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1992-02-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Davis, Paul H; Chen, Minghe; Zhang, Xiaochun et al. (2009) Proteomic comparison of Entamoeba histolytica and Entamoeba dispar and the role of E. histolytica alcohol dehydrogenase 3 in virulence. PLoS Negl Trop Dis 3:e415
Sperandio, Brice; Regnault, Beatrice; Guo, Jianhua et al. (2008) Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression. J Exp Med 205:1121-32
Snow, Margaret; Chen, Minghe; Guo, Jian et al. (2008) Differences in complement-mediated killing of Entamoeba histolytica between men and women--an explanation for the increased susceptibility of men to invasive amebiasis? Am J Trop Med Hyg 78:922-3
Davis, Paul H; Schulze, Jochen; Stanley Jr, Samuel L (2007) Transcriptomic comparison of two Entamoeba histolytica strains with defined virulence phenotypes identifies new virulence factor candidates and key differences in the expression patterns of cysteine proteases, lectin light chains, and calmodulin. Mol Biochem Parasitol 151:118-28
Melendez-Lopez, Samuel G; Herdman, Scott; Hirata, Ken et al. (2007) Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model. Eukaryot Cell 6:1130-6
Bullok, Kristin E; Maxwell, Dustin; Kesarwala, Aparna H et al. (2007) Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. Biochemistry 46:4055-65
Stanley Jr, S L (2006) Vaccines for amoebiasis: barriers and opportunities. Parasitology 133 Suppl:S81-6
Pelosof, Lorraine C; Davis, Paul H; Zhang, Zhi et al. (2006) Co-ordinate but disproportionate activation of apoptotic, regenerative and inflammatory pathways characterizes the liver response to acute amebic infection. Cell Microbiol 8:508-22
Davis, Paul H; Zhang, Xiaochun; Guo, Jianhua et al. (2006) Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence. Mol Microbiol 61:1523-32
Snow, Margaret J; Stanley Jr, Samuel L (2006) Recent progress in vaccines for amebiasis. Arch Med Res 37:280-7

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