Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI030534-06
Application #
2065682
Study Section
Biochemistry Study Section (BIO)
Project Start
1990-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Vermont & St Agric College
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Zhang, Zhenxi; Burke, John M (2005) Inhibition of viral replication by ribozyme: mutational analysis of the site and mechanism of antiviral activity. J Virol 79:3728-36
Seyhan, Attila A; Vitiello, Danielle; Shields, Michele T et al. (2002) Ribozyme inhibition of alphavirus replication. J Biol Chem 277:25957-62
zu Putlitz, J; Yu, Q; Burke, J M et al. (1999) Combinatorial screening and intracellular antiviral activity of hairpin ribozymes directed against hepatitis B virus. J Virol 73:5381-7
Murray, J B; Seyhan, A A; Walter, N G et al. (1998) The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone. Chem Biol 5:587-95
Yu, Q; Pecchia, D B; Kingsley, S L et al. (1998) Cleavage of highly structured viral RNA molecules by combinatorial libraries of hairpin ribozymes. The most effective ribozymes are not predicted by substrate selection rules. J Biol Chem 273:23524-33
Berzal-Herranz, A; Burke, J M (1997) Ligation of RNA molecules by the hairpin ribozyme. Methods Mol Biol 74:349-55
Yu, Q; Burke, J M (1997) Design of hairpin ribozymes for in vitro and cellular applications. Methods Mol Biol 74:161-9
Sargueil, B; Burke, J M (1997) In vitro selection of hairpin ribozymes. Methods Mol Biol 74:289-300
Sargueil, B; Pecchia, D B; Burke, J M (1995) An improved version of the hairpin ribozyme functions as a ribonucleoprotein complex. Biochemistry 34:7739-48
Butcher, S E; Heckman, J E; Burke, J M (1995) Reconstitution of hairpin ribozyme activity following separation of functional domains. J Biol Chem 270:29648-51