Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI030927-06A1S1
Application #
2065993
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1991-08-01
Project End
2001-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Garcia, Erin I; Emerman, Michael (2018) Recurrent Loss of APOBEC3H Activity during Primate Evolution. J Virol :
OhAinle, Molly; Helms, Louisa; Vermeire, Jolien et al. (2018) A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV. Elife 7:
Roesch, Ferdinand; OhAinle, Molly; Emerman, Michael (2018) A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery. Retrovirology 15:26
Adolph, Madison B; Ara, Anjuman; Feng, Yuqing et al. (2017) Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization. Nucleic Acids Res 45:3378-3394
McLaughlin Jr, Richard N; Gable, Jacob T; Wittkopp, Cristina J et al. (2016) Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution. Mol Biol Evol 33:1889-901
Fregoso, Oliver I; Emerman, Michael (2016) Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment. MBio 7:
Wittkopp, Cristina J; Adolph, Madison B; Wu, Lily I et al. (2016) A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses. PLoS Pathog 12:e1005865
Mitchell, Patrick S; Young, Janet M; Emerman, Michael et al. (2015) Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction. PLoS Pathog 11:e1005304
Matsen 4th, Frederick A; Small, Christopher T; Soliven, Khanh et al. (2014) A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses. PLoS Comput Biol 10:e1003493
Refsland, Eric W; Hultquist, Judd F; Luengas, Elizabeth M et al. (2014) Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity. PLoS Genet 10:e1004761

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