Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI031338-05
Application #
2066300
Study Section
Special Emphasis Panel (ZRG5-ARRE (01))
Project Start
1991-04-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Jia, Qingmei; Dillon, Barbara Jane; Masleša-Gali?, Saša et al. (2017) Listeria-vectored vaccine expressing the Mycobacterium tuberculosis 30 kDa major secretory protein via the constitutively active prfA* regulon boosts BCG efficacy against tuberculosis. Infect Immun :
Gillis, Thomas P; Tullius, Michael V; Horwitz, Marcus A (2014) rBCG30-induced immunity and cross-protection against Mycobacterium leprae challenge are enhanced by boosting with the Mycobacterium tuberculosis 30-kilodalton antigen 85B. Infect Immun 82:3900-9
Horwitz, Marcus A; Harth, Günter; Dillon, Barbara Jane et al. (2009) Commonly administered BCG strains including an evolutionarily early strain and evolutionarily late strains of disparate genealogy induce comparable protective immunity against tuberculosis. Vaccine 27:441-5
Hoft, Daniel F; Blazevic, Azra; Abate, Getahun et al. (2008) A new recombinant bacille Calmette-Guerin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers. J Infect Dis 198:1491-501
Tullius, Michael V; Harth, Gunter; Maslesa-Galic, Sasa et al. (2008) A Replication-Limited Recombinant Mycobacterium bovis BCG vaccine against tuberculosis designed for human immunodeficiency virus-positive persons is safer and more efficacious than BCG. Infect Immun 76:5200-14
Horwitz, Marcus A; Harth, Gunter; Dillon, Barbara Jane et al. (2006) A novel live recombinant mycobacterial vaccine against bovine tuberculosis more potent than BCG. Vaccine 24:1593-600
Horwitz, Marcus A; Harth, Gunter; Dillon, Barbara Jane et al. (2006) Extraordinarily few organisms of a live recombinant BCG vaccine against tuberculosis induce maximal cell-mediated and protective immunity. Vaccine 24:443-51
Horwitz, Marcus A; Harth, Gunter; Dillon, Barbara Jane et al. (2005) Enhancing the protective efficacy of Mycobacterium bovis BCG vaccination against tuberculosis by boosting with the Mycobacterium tuberculosis major secretory protein. Infect Immun 73:4676-83
Horwitz, Marcus A (2005) Recombinant BCG expressing Mycobacterium tuberculosis major extracellular proteins. Microbes Infect 7:947-54
Harth, Gunter; Maslesa-Galic, Sasa; Tullius, Michael V et al. (2005) All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis. Mol Microbiol 58:1157-72

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