Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI031558-05
Application #
2066536
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1995-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Ortiz, B D; Harrow, F; Cado, D et al. (2001) Function and factor interactions of a locus control region element in the mouse T cell receptor-alpha/Dad1 gene locus. J Immunol 167:3836-45
Hong, N A; Flannery, M; Hsieh, S N et al. (2000) Mice lacking Dad1, the defender against apoptotic death-1, express abnormal N-linked glycoproteins and undergo increased embryonic apoptosis. Dev Biol 220:76-84
Santoso, B; Ortiz, B D; Winoto, A (2000) Control of organ-specific demethylation by an element of the T-cell receptor-alpha locus control region. J Biol Chem 275:1952-8
Ortiz, B D; Cado, D; Winoto, A (1999) A new element within the T-cell receptor alpha locus required for tissue-specific locus control region activity. Mol Cell Biol 19:1901-9
Hong, N A; Kabra, N H; Hsieh, S N et al. (1999) In vivo overexpression of Dad1, the defender against apoptotic death-1, enhances T cell proliferation but does not protect against apoptosis. J Immunol 163:1888-93
Hong, N A; Cado, D; Mitchell, J et al. (1997) A targeted mutation at the T-cell receptor alpha/delta locus impairs T-cell development and reveals the presence of the nearby antiapoptosis gene Dad1. Mol Cell Biol 17:2151-7
Ortiz, B D; Cado, D; Chen, V et al. (1997) Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues. EMBO J 16:5037-45
Smith, V M; Lee, P P; Szychowski, S et al. (1995) GATA-3 dominant negative mutant. Functional redundancy of the T cell receptor alpha and beta enhancers. J Biol Chem 270:1515-20