Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI031806-09
Application #
6349800
Study Section
Special Emphasis Panel (ZRG1-AARR-1 (01))
Program Officer
Sharma, Opendra K
Project Start
1991-09-01
Project End
2003-01-31
Budget Start
2001-02-01
Budget End
2002-01-31
Support Year
9
Fiscal Year
2001
Total Cost
$409,271
Indirect Cost
Name
Johns Hopkins University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Liao, Zhaohao; Graham, David R; Hildreth, James E K (2003) Lipid rafts and HIV pathogenesis: virion-associated cholesterol is required for fusion and infection of susceptible cells. AIDS Res Hum Retroviruses 19:675-87
Nguyen, Deborah Greene; Hildreth, James E K (2003) Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages. Eur J Immunol 33:483-93
Graham, David R M; Chertova, Elena; Hilburn, Joanne M et al. (2003) Cholesterol depletion of human immunodeficiency virus type 1 and simian immunodeficiency virus with beta-cyclodextrin inactivates and permeabilizes the virions: evidence for virion-associated lipid rafts. J Virol 77:8237-48
Banks, Nia D; Kinsey, Nicole; Clements, Janice et al. (2002) Sustained antibody-dependent cell-mediated cytotoxicity (ADCC) in SIV-infected macaques correlates with delayed progression to AIDS. AIDS Res Hum Retroviruses 18:1197-205
Speck, R Renae; Yu, Xiao-Fang; Hildreth, James et al. (2002) Differential effects of p-glycoprotein and multidrug resistance protein-1 on productive human immunodeficiency virus infection. J Infect Dis 186:332-40
Liao, Z; Cimakasky, L M; Hampton, R et al. (2001) Lipid rafts and HIV pathogenesis: host membrane cholesterol is required for infection by HIV type 1. AIDS Res Hum Retroviruses 17:1009-19
Niyogi, K; Hildreth, J E (2001) Characterization of new syncytium-inhibiting monoclonal antibodies implicates lipid rafts in human T-cell leukemia virus type 1 syncytium formation. J Virol 75:7351-61
Liao, Z; Roos, J W; Hildreth, J E (2000) Increased infectivity of HIV type 1 particles bound to cell surface and solid-phase ICAM-1 and VCAM-1 through acquired adhesion molecules LFA-1 and VLA-4. AIDS Res Hum Retroviruses 16:355-66
Iyengar, S; Schwartz, D H; Clements, J E et al. (2000) CD4-independent, CCR5-dependent simian immunodeficiency virus infection and chemotaxis of human cells. J Virol 74:6720-4
Nguyen, D H; Hildreth, J E (2000) Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts. J Virol 74:3264-72

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