Abstract

Investigator=s Abstract) The World Health Organization estimates that 10 million HIV-infected individuals will die of tuberculosis (TB) during the decade of the 1990's. Although HIV-infected patients with TB respond to effective antituberculous therapy, their prognosis remains poor. Early deaths are often attributable to TB, but later deaths result from complications of HIV infection other than tuberculosis. Recent epidemiologic observations indicate that TB reduces survival and increases the rate of opportunistic infections in HIV-infected patients. Mounting evidence from immunologic and virologic studies supports the concept of co-pathogenesis in which immune activation triggered by tuberculosis, and mediated by cytokines such as tumor necrosis factor-alpha (TNFa), stimulates viral replication, increases viral load, and accelerates HIV infection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI032414-09
Application #
6373261
Study Section
Special Emphasis Panel (ZRG1-AARR-6 (01))
Program Officer
Laughon, Barbara E
Project Start
1992-07-01
Project End
2004-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
9
Fiscal Year
2001
Total Cost
$712,293
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Mupere, Ezekiel; Malone, LaShaunda; Zalwango, Sarah et al. (2014) Wasting among Uganda men with pulmonary tuberculosis is associated with linear regain in lean tissue mass during and after treatment in contrast to women with wasting who regain fat tissue mass: prospective cohort study. BMC Infect Dis 14:24
Jaganath, Devan; Zalwango, Sarah; Okware, Brenda et al. (2013) Contact investigation for active tuberculosis among child contacts in Uganda. Clin Infect Dis 57:1685-92
Mupere, Ezekiel; Malone, Lashaunda; Zalwango, Sarah et al. (2012) Lean tissue mass wasting is associated with increased risk of mortality among women with pulmonary tuberculosis in urban Uganda. Ann Epidemiol 22:466-73
Mupere, Ezekiel; Zalwango, Sarah; Chiunda, Allan et al. (2010) Body composition among HIV-seropositive and HIV-seronegative adult patients with pulmonary tuberculosis in Uganda. Ann Epidemiol 20:210-6
Srikantiah, P; Lin, R; Walusimbi, M et al. (2007) Elevated HIV seroprevalence and risk behavior among Ugandan TB suspects: implications for HIV testing and prevention. Int J Tuberc Lung Dis 11:168-74
Jones-Lopez, Edward C; Okwera, Alphonse; Mayanja-Kizza, Harriet et al. (2006) Delayed-type hypersensitivity skin test reactivity and survival in HIV-infected patients in Uganda: should anergy be a criterion to start antiretroviral therapy in low-income countries? Am J Trop Med Hyg 74:154-61
Mayanja-Kizza, Harriet; Jones-Lopez, Edward; Okwera, Alphonse et al. (2005) Immunoadjuvant prednisolone therapy for HIV-associated tuberculosis: a phase 2 clinical trial in Uganda. J Infect Dis 191:856-65
Van Lettow, M; Kumwenda, J J; Harries, A D et al. (2004) Malnutrition and the severity of lung disease in adults with pulmonary tuberculosis in Malawi. Int J Tuberc Lung Dis 8:211-7
Shah, S; Whalen, C; Kotler, D P et al. (2001) Severity of human immunodeficiency virus infection is associated with decreased phase angle, fat mass and body cell mass in adults with pulmonary tuberculosis infection in Uganda. J Nutr 131:2843-7
Whalen, C C; Nsubuga, P; Okwera, A et al. (2000) Impact of pulmonary tuberculosis on survival of HIV-infected adults: a prospective epidemiologic study in Uganda. AIDS 14:1219-28

Showing the most recent 10 out of 13 publications