Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI032524-05
Application #
2067423
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1992-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Ru, Heng; Mi, Wei; Zhang, Pengfei et al. (2018) DNA melting initiates the RAG catalytic pathway. Nat Struct Mol Biol 25:732-742
Shetty, Keerthi; Schatz, David G (2015) Recruitment of RAG1 and RAG2 to Chromatinized DNA during V(D)J Recombination. Mol Cell Biol 35:3701-13
Hu, Jiazhi; Zhang, Yu; Zhao, Lijuan et al. (2015) Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes. Cell 163:947-59
Rodgers, William; Byrum, Jennifer N; Sapkota, Hem et al. (2015) Spatio-temporal regulation of RAG2 following genotoxic stress. DNA Repair (Amst) 27:19-27
Ciubotaru, Mihai; Surleac, Marius D; Metskas, Lauren Ann et al. (2015) The architecture of the 12RSS in V(D)J recombination signal and synaptic complexes. Nucleic Acids Res 43:917-31
Banerjee, Joydeep K; Schatz, David G (2014) Synapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” rule. Mol Cell Biol 34:2566-80
Ciubotaru, Mihai; Trexler, Adam J; Spiridon, Laurentiu N et al. (2013) RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes. Nucleic Acids Res 41:2437-54
Little, Alicia J; Corbett, Elizabeth; Ortega, Fabian et al. (2013) Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA. Nucleic Acids Res 41:3289-301
Subrahmanyam, Ramesh; Du, Hansen; Ivanova, Irina et al. (2012) Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions. Nat Immunol 13:1205-12
Ji, Yanhong; Little, Alicia J; Banerjee, Joydeep K et al. (2010) Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination. J Exp Med 207:2809-16

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