Receptor Editing In B Cells

Nemazee, David

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI033608-12
• Application #: 6685172
• Study Section: Allergy and Immunology Study Section (ALY)
• Program Officer: Kirkham, Perry M
• Project Start: 1992-12-01
• Project End: 2007-11-30
• Budget Start: 2003-12-01
• Budget End: 2004-11-30
• Support Year: 12
• Fiscal Year: 2004
• Total Cost: $375,400

Institution

• Name: Scripps Research Institute
• DUNS #: 781613492
• City: La Jolla
• State: CA
• Country: United States
• Zip Code: 92037

Publications

Aoki-Ota, Miyo; Torkamani, Ali; Ota, Takayuki et al. (2012) Skewed primary Ig? repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing. J Immunol 188:2305-15

Tiegs, Susan L; Russell, David M; Nemazee, David (2011) Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020. J Immunol 186:1313-24

Ota, Miyo; Duong, Bao H; Torkamani, Ali et al. (2010) Regulation of the B cell receptor repertoire and self-reactivity by BAFF. J Immunol 185:4128-36

Beck, Kristina; Peak, Mandy M; Ota, Takayuki et al. (2009) Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci. J Exp Med 206:2271-84

Huber, Christoph; Martensson, Annica; Bokoch, Gary M et al. (2008) FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J Biol Chem 283:34002-12

Vela, Jose Luis; Ait-Azzouzene, Djemel; Duong, Bao Hoa et al. (2008) Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production. Immunity 28:161-70

Verkoczy, Laurent; Duong, Bao; Skog, Patrick et al. (2007) Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. J Immunol 178:6332-41

Verkoczy, Laurent; Ait-Azzouzene, Djemel; Skog, Patrick et al. (2005) A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. Immunity 22:519-31

Ait-Azzouzene, Djemel; Skog, Patrick; Retter, Marc et al. (2004) Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection. Immunol Rev 197:219-30

Verkoczy, Laurent K; Martensson, Annica S; Nemazee, David (2004) The scope of receptor editing and its association with autoimmunity. Curr Opin Immunol 16:808-14