Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI033613-04
Application #
2068684
Study Section
Experimental Immunology Study Section (EI)
Project Start
1993-09-01
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
National Jewish Health
Department
Type
DUNS #
City
Denver
State
CO
Country
United States
Zip Code
80206
Detanico, Thiago; St Clair, James B; Aviszus, Katja et al. (2013) Somatic mutagenesis in autoimmunity. Autoimmunity 46:102-14
Aviszus, Katja; Macleod, Megan K L; Kirchenbaum, Greg A et al. (2012) Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells. J Immunol 189:4275-83
Heiser, Ryan A; Snyder, Christopher M; St Clair, James et al. (2011) Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide. J Immunol 187:212-21
Detanico, Thiago; Heiser, Ryan A; Aviszus, Katja et al. (2011) Self-tolerance checkpoints in CD4 T cells specific for a peptide derived from the B cell antigen receptor. J Immunol 187:82-91
Guo, Wenzhong; Smith, Diana; Aviszus, Katja et al. (2010) Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity. J Exp Med 207:2225-37
Guth, A; Detanico, T; Smith, D et al. (2009) Spontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3. Lupus 18:299-308
Aviszus, Katja; Zhang, Xianghua; Wysocki, Lawrence J (2007) Silent development of memory progenitor B cells. J Immunol 179:5181-90
Wysocki, L J; Liu, A H; Jena, P K (1998) Somatic mutagenesis and evolution of memory B cells. Curr Top Microbiol Immunol 229:105-31
Portanova, J P; Creadon, G; Zhang, X et al. (1995) An early post-mutational selection event directs expansion of autoreactive B cells in murine lupus. Mol Immunol 32:117-35
Eyerman, M C; Wysocki, L (1994) T cell recognition of somatically-generated Ab diversity. J Immunol 152:1569-77

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