Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI033696-05
Application #
2068750
Study Section
Special Emphasis Panel (SRC (59))
Project Start
1992-09-30
Project End
1997-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Biochemistry
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Quartararo, Christine E; Hazra, Saugata; Hadi, Timin et al. (2013) Structural, kinetic and chemical mechanism of isocitrate dehydrogenase-1 from Mycobacterium tuberculosis. Biochemistry 52:1765-75
Serrano, Hector; Blanchard, John S (2013) Kinetic and isotopic characterization of L-proline dehydrogenase from Mycobacterium tuberculosis. Biochemistry 52:5009-15
Chow, Carmen; Xu, Hua; Blanchard, John S (2013) Kinetic characterization of hydrolysis of nitrocefin, cefoxitin, and meropenem by ?-lactamase from Mycobacterium tuberculosis. Biochemistry 52:4097-104
Czekster, Clarissa M; Blanchard, John S (2012) One substrate, five products: reactions catalyzed by the dihydroneopterin aldolase from Mycobacterium tuberculosis. J Am Chem Soc 134:19758-71
Xu, Hua; Hazra, Saugata; Blanchard, John S (2012) NXL104 irreversibly inhibits the ?-lactamase from Mycobacterium tuberculosis. Biochemistry 51:4551-7
Czekster, Clarissa M; Vandemeulebroucke, An; Blanchard, John S (2011) Two parallel pathways in the kinetic sequence of the dihydrofolate reductase from Mycobacterium tuberculosis. Biochemistry 50:7045-56
Hegde, Subray S; Vetting, Matthew W; Mitchenall, Lesley A et al. (2011) Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor. Antimicrob Agents Chemother 55:110-7
Vetting, Matthew W; Hegde, Subray S; Zhang, Yong et al. (2011) Pentapeptide-repeat proteins that act as topoisomerase poison resistance factors have a common dimer interface. Acta Crystallogr Sect F Struct Biol Cryst Commun 67:296-302
Czekster, Clarissa M; Vandemeulebroucke, An; Blanchard, John S (2011) Kinetic and chemical mechanism of the dihydrofolate reductase from Mycobacterium tuberculosis. Biochemistry 50:367-75
Vetting, Matthew W; Hegde, Subray S; Wang, Minghua et al. (2011) Structure of QnrB1, a plasmid-mediated fluoroquinolone resistance factor. J Biol Chem 286:25265-73

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