Abstract

This is an application to study tolerance induction by a peptide (12-26) epitope of a bacteriophage lambda protein fused at the N-terminus of an IgG heavy chain. Injection of the myeloma fusion protein or transduction of bone marrow cells with the gene for this fusion protein have both led to B-cell unresponsiveness in vivo. The investigators suggest that this system offers a novel approach for immunotherapy of autoimmune diseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI035622-03
Application #
2886901
Study Section
Immunobiology Study Section (IMB)
Program Officer
Collier, Elaine S
Project Start
1997-05-01
Project End
2001-04-30
Budget Start
1999-05-01
Budget End
2000-04-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
American National Red Cross
Department
Type
DUNS #
003255213
City
Washington
State
DC
Country
United States
Zip Code
20006

  Publications

Kim, Yong Chan; Zhang, Ai-Hong; Yoon, Jeongheon et al. (2018) Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells. J Autoimmun 92:77-86
Scott, D W (2014) Inhibitors - cellular aspects and novel approaches for tolerance. Haemophilia 20 Suppl 4:80-6
Su, Yan; Rossi, Robert; De Groot, Anne S et al. (2013) Regulatory T cell epitopes (Tregitopes) in IgG induce tolerance in vivo and lack immunogenicity per se. J Leukoc Biol 94:377-83
Adair, Patrick; Su, Yan; Scott, David W (2013) Tolerance induction in hemophilia A animal models: battling inhibitors with antigen-specific immunotherapies. Discov Med 15:275-82
Scott, David W; Lozier, Jay N (2012) Gene therapy for haemophilia: prospects and challenges to prevent or reverse inhibitor formation. Br J Haematol 156:295-302
Scott, David W; Zhang, Ai-Hong; Su, Yan (2012) B-cell based gene therapy for autoimmune diseases. Infect Disord Drug Targets 12:241-7
Melamed, Doron; Scott, David W (2012) Aging and neoteny in the B lineage. Blood 120:4143-9
Matheu, Melanie P; Su, Yan; Greenberg, Milton L et al. (2012) Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance. Proc Natl Acad Sci U S A 109:E1258-66
Su, Yan; Zhang, Ai-Hong; Noben-Trauth, Nancy et al. (2011) B-Cell Gene Therapy for Tolerance Induction: Host but Not Donor B-Cell Derived IL-10 is Necessary for Tolerance. Front Microbiol 2:154
Su, Yan; Zhang, Ai-Hong; Li, Xin et al. (2011) B cells ""transduced"" with TAT-fusion proteins can induce tolerance and protect mice from diabetes and EAE. Clin Immunol 140:260-7

Showing the most recent 10 out of 28 publications