Childhood asthma causes substantial morbidity and health care costs. Of the 18 million asthmatics in the United States, roughly 10 million are children under the age of 16. Asthma is the most common admitting diagnosis to pediatric hospitals in the United States, and asthma accounts for 2.8 million office visits per year in the United States. It is estimated that the cost of asthma care in children accounts for over $6 billion in health care costs per year. We propose to conduct a prospective longitudinal cohort study to examine the role of allergen exposure in the home on the development of two main outcomes: 1) asthma/wheeze during infancy and early childhood; 2) allergic sensitization, as measured by skin test reactivity (during early childhood). The primary allergen exposures of interest include house dust mite (der p I, der f I), fungi, cockroach (bla g I), and cat (fel d I) antigens. Additional exposures will be examined that may impact the association between allergens and the two main outcomes. These exposures include: heredity, assessed via family history of allergy and/or asthma, and via cord blood IgE; in utero and postnatal tobacco smoke exposure; acute lower respiratory illness; gender; race; socioeconomic status; and perinatal factors. If allergen exposure proves to be important in the prediction of sensitization and the development of asthma/wheeze in early life, it is a finding of great public health significance, as control of exposure measures could be instituted which could potentially minimize sensitization and exposure and, hence, the development of the disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI035786-04
Application #
2376374
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1994-06-01
Project End
1999-02-28
Budget Start
1997-03-01
Budget End
1998-02-28
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
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Hanson, Blake; Zhou, Yanjiao; Bautista, Eddy J et al. (2016) Characterization of the bacterial and fungal microbiome in indoor dust and outdoor air samples: a pilot study. Environ Sci Process Impacts 18:713-24
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Sordillo, Joanne E; Kelly, Roxanne; Bunyavanich, Supinda et al. (2015) Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity. J Allergy Clin Immunol 136:885-92.e2
Tse, Sze Man; Coull, Brent A; Sordillo, Joanne E et al. (2015) Gender- and age-specific risk factors for wheeze from birth through adolescence. Pediatr Pulmonol 50:955-62
Bunyavanich, Supinda; Rifas-Shiman, Sheryl L; Platts-Mills, Thomas A et al. (2014) Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children. J Allergy Clin Immunol 133:1373-82
Bunyavanich, Supinda; Rifas-Shiman, Sheryl L; Platts-Mills, Thomas A E et al. (2014) Peanut allergy prevalence among school-age children in a US cohort not selected for any disease. J Allergy Clin Immunol 134:753-5
Behbod, B; Sordillo, J E; Hoffman, E B et al. (2013) Wheeze in infancy: protection associated with yeasts in house dust contrasts with increased risk associated with yeasts in indoor air and other fungal taxa. Allergy 68:1410-8
Cook, Andrea J; Gold, Diane R; Li, Yi (2013) Spatial Cluster Detection for Longitudinal Outcomes using Administrative Regions. Commun Stat Theory Methods 42:2105-2117
Tse, Sze Man; Gold, Diane R; Sordillo, Joanne E et al. (2013) Diagnostic accuracy of the bronchodilator response in children. J Allergy Clin Immunol 132:554-559.e5

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