Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
7R01AI036396-08
Application #
6543098
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Program Officer
Sizemore, Christine F
Project Start
1994-08-01
Project End
2005-01-31
Budget Start
2001-05-01
Budget End
2002-01-31
Support Year
8
Fiscal Year
2001
Total Cost
$166,581
Indirect Cost
Name
University of Washington
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Adams, Kristin N; Szumowski, John D; Ramakrishnan, Lalita (2014) Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis 210:456-66
Petrie, Timothy A; Strand, Nicholas S; Yang, Chao-Tsung et al. (2014) Macrophages modulate adult zebrafish tail fin regeneration. Development 141:2581-91
Cambier, C J; Takaki, Kevin K; Larson, Ryan P et al. (2014) Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. Nature 505:218-22
Ramakrishnan, Lalita (2013) Looking within the zebrafish to understand the tuberculous granuloma. Adv Exp Med Biol 783:251-66
Tobin, David M; Roca, Francisco J; Ray, John P et al. (2013) An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. PLoS One 8:e67828
Takaki, Kevin; Davis, J Muse; Winglee, Kathryn et al. (2013) Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish. Nat Protoc 8:1114-24
Roca, Francisco J; Ramakrishnan, Lalita (2013) TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Cell 153:521-34
Szumowski, John D; Adams, Kristin N; Edelstein, Paul H et al. (2013) Antimicrobial efflux pumps and Mycobacterium tuberculosis drug tolerance: evolutionary considerations. Curr Top Microbiol Immunol 374:81-108
Tobin, David M; Ramakrishnan, Lalita (2013) TB: the Yin and Yang of lipid mediators. Curr Opin Pharmacol 13:641-5
Yang, Chao-Tsung; Cambier, C J; Davis, J Muse et al. (2012) Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages. Cell Host Microbe 12:301-12

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