Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
7R01AI037584-04
Application #
2672461
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1995-09-30
Project End
1999-07-31
Budget Start
1998-01-01
Budget End
1998-07-31
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Pathology
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Chang, John T; Ciocca, Maria L; Kinjyo, Ichiko et al. (2011) Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity 34:492-504
Andreotti, Amy H; Schwartzberg, Pamela L; Joseph, Raji E et al. (2010) T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harb Perspect Biol 2:a002287
Min, Lie; Wu, Wenfang; Joseph, Raji E et al. (2010) Disrupting the intermolecular self-association of Itk enhances T cell signaling. J Immunol 184:4228-35
Sacristán, Catarina; Schattgen, Stefan A; Berg, Leslie J et al. (2009) Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells. Eur J Immunol 39:2584-95
Felices, Martin; Yin, Catherine C; Kosaka, Yoko et al. (2009) Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo. Proc Natl Acad Sci U S A 106:8308-13
Shi, Min; Lin, Tsung H; Appell, Kenneth C et al. (2009) Cell cycle progression following naive T cell activation is independent of Jak3/common gamma-chain cytokine signals. J Immunol 183:4493-501
Prince, Amanda L; Yin, Catherine C; Enos, Megan E et al. (2009) The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development. Immunol Rev 228:115-31
Felices, Martin; Berg, Leslie J (2008) The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. J Immunol 180:3007-18
Shi, Min; Lin, Tsung H; Appell, Kenneth C et al. (2008) Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity 28:763-73
Lucas, Julie A; Felices, Martin; Evans, John W et al. (2007) Subtle defects in pre-TCR signaling in the absence of the Tec kinase Itk. J Immunol 179:7561-7

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