Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
7R01AI037601-02
Application #
2074418
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1995-04-01
Project End
2000-03-31
Budget Start
1995-11-01
Budget End
1996-03-31
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Genetics
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Lin, Yi-Pin; Bhowmick, Rudra; Coburn, Jenifer et al. (2015) Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete. Cell Microbiol 17:1464-76
Lin, Yi-Pin; Chen, Qiang; Ritchie, Jennifer A et al. (2015) Glycosaminoglycan binding by Borrelia burgdorferi adhesin BBK32 specifically and uniquely promotes joint colonization. Cell Microbiol 17:860-75
Lin, Yi-Pin; Benoit, Vivian; Yang, Xiuli et al. (2014) Strain-specific variation of the decorin-binding adhesin DbpA influences the tissue tropism of the lyme disease spirochete. PLoS Pathog 10:e1004238
Benoit, Vivian M; Fischer, Joshua R; Lin, Yi-Pin et al. (2011) Allelic variation of the Lyme disease spirochete adhesin DbpA influences spirochetal binding to decorin, dermatan sulfate, and mammalian cells. Infect Immun 79:3501-9
Benoit, Vivian M; Petrich, Annett; Alugupalli, Kishore R et al. (2010) Genetic control of the innate immune response to Borrelia hermsii influences the course of relapsing fever in inbred strains of mice. Infect Immun 78:586-94
Chen, Qiang; Fischer, Joshua R; Benoit, Vivian M et al. (2008) In vitro CpG methylation increases the transformation efficiency of Borrelia burgdorferi strains harboring the endogenous linear plasmid lp56. J Bacteriol 190:7885-91
Weening, Eric H; Parveen, Nikhat; Trzeciakowski, Jerome P et al. (2008) Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection. Infect Immun 76:5694-705
Alugupalli, Kishore R; Akira, Shizuo; Lien, Egil et al. (2007) MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol 178:3740-9
Fischer, Joshua R; LeBlanc, Kimberly T; Leong, John M (2006) Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycans. Infect Immun 74:435-41
Parveen, Nikhat; Cornell, Kenneth A; Bono, James L et al. (2006) Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice. Infect Immun 74:3016-20

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