Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI037691-02
Application #
2074538
Study Section
Special Emphasis Panel (SRC (23))
Project Start
1995-03-15
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Marangoni, Francesco; Zhang, Ruan; Mani, Vinidhra et al. (2018) Tumor Tolerance-Promoting Function of Regulatory T Cells Is Optimized by CD28, but Strictly Dependent on Calcineurin. J Immunol 200:3647-3661
Alessandrini, Alessandro; Turka, Laurence A (2017) FOXP3-Positive Regulatory T Cells and Kidney Allograft Tolerance. Am J Kidney Dis 69:667-674
Kamphorst, Alice O; Wieland, Andreas; Nasti, Tahseen et al. (2017) Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science 355:1423-1427
Zhang, Ruan; Sage, Peter T; Finn, Kelsey et al. (2017) B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. J Immunol 199:3972-3980
Kean, Leslie S; Turka, Laurence A; Blazar, Bruce R (2017) Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy. Immunol Rev 276:192-212
Zhang, Ruan; Borges, Christopher M; Fan, Martin Y et al. (2015) Requirement for CD28 in Effector Regulatory T Cell Differentiation, CCR6 Induction, and Skin Homing. J Immunol 195:4154-61
Vergani, Andrea; Gatti, Francesca; Lee, Kang M et al. (2015) TIM4 Regulates the Anti-Islet Th2 Alloimmune Response. Cell Transplant 24:1599-1614
Kim, James I; Turka, Laurence A (2015) Transplant tolerance: a new role for IL-34. J Clin Invest 125:3751-3
McDonald-Hyman, Cameron; Turka, Laurence A; Blazar, Bruce R (2015) Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation. Sci Transl Med 7:280rv2
Kawai, Tatsuo; Leventhal, Joseph; Madsen, Joren C et al. (2014) Tolerance: one transplant for life. Transplantation 98:117-21

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