Abstract

The hypothesis is postulated that microchimerism arising from pregnancy contributes to the pathogenesis of scleroderma.
Five specific aims will be addressed; three test the hypothesis that maternal-fetal-HLA-compatibility increases the risk of subsequent scleroderma. These studies will examine patients and their children as well as patients and their mothers. The remaining two aims will seek proof of non-host cells in the blood and tissues of scleroderma patients. If persistent fetal cells are involved in the pathogenesis of scleroderma, they could be targeted for selective elimination.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI041721-02
Application #
2673074
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1997-07-01
Project End
2001-05-31
Budget Start
1998-06-01
Budget End
1999-05-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109

  Publications

Kamper-Jørgensen, Mads; Gammill, Hilary S; Nelson, J Lee (2018) Preeclampsia and scleroderma: a prospective nationwide analysis. Acta Obstet Gynecol Scand 97:587-590
Gentil, Coline A; Gammill, Hilary S; Luu, Christine T et al. (2017) Characterization of the HLA-DR?1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis. Arthritis Res Ther 19:46
Guthrie, Katherine A; Gammill, Hilary S; Kamper-Jørgensen, Mads et al. (2016) Statistical Methods for Unusual Count Data: Examples From Studies of Microchimerism. Am J Epidemiol 184:779-786
Stevens, Anne M; Kanaan, Sami B; Torok, Kathryn S et al. (2016) Brief Report: HLA-DRB1, DQA1, and DQB1 in Juvenile-Onset Systemic Sclerosis. Arthritis Rheumatol 68:2772-2777
Ma, Kimberly K; Nelson, J Lee; Guthrie, Katherine A et al. (2014) Adverse pregnancy outcomes and risk of subsequent rheumatoid arthritis. Arthritis Rheumatol 66:508-12
Gammill, Hilary S; Aydelotte, Tessa M; Guthrie, Katherine A et al. (2013) Cellular fetal microchimerism in preeclampsia. Hypertension 62:1062-7
Inamoto, Yoshihiro; Storer, Barry E; Petersdorf, Effie W et al. (2013) Incidence, risk factors, and outcomes of sclerosis in patients with chronic graft-versus-host disease. Blood 121:5098-103
Chan, William F N; Atkins, Christopher J; Naysmith, David et al. (2012) Microchimerism in the rheumatoid nodules of patients with rheumatoid arthritis. Arthritis Rheum 64:380-8
Nelson, J Lee (2012) The otherness of self: microchimerism in health and disease. Trends Immunol 33:421-7
Chan, William F N; Gurnot, Cécile; Montine, Thomas J et al. (2012) Male microchimerism in the human female brain. PLoS One 7:e45592

Showing the most recent 10 out of 59 publications