Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI042738-06
Application #
6620923
Study Section
Biochemistry Study Section (BIO)
Program Officer
Schaefer, Michael R
Project Start
1998-02-01
Project End
2007-01-31
Budget Start
2003-02-01
Budget End
2004-01-31
Support Year
6
Fiscal Year
2003
Total Cost
$420,046
Indirect Cost
Name
Harvard University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
Parker, Jared B; Walsh, Christopher T (2012) Stereochemical outcome at four stereogenic centers during conversion of prephenate to tetrahydrotyrosine by BacABGF in the bacilysin pathway. Biochemistry 51:5622-32
Parker, Jared B; Walsh, Christopher T (2012) Olefin isomerization regiochemistries during tandem action of BacA and BacB on prephenate in bacilysin biosynthesis. Biochemistry 51:3241-51
Wencewicz, Timothy A; Walsh, Christopher T (2012) Pseudomonas syringae self-protection from tabtoxinine-?-lactam by ligase TblF and acetylase Ttr. Biochemistry 51:7712-25
Walsh, Christopher T; Fischbach, Michael A (2010) Natural products version 2.0: connecting genes to molecules. J Am Chem Soc 132:2469-93
Fischbach, Michael A; Walsh, Christopher T (2009) Antibiotics for emerging pathogens. Science 325:1089-93
Heemstra Jr, John R; Walsh, Christopher T; Sattely, Elizabeth S (2009) Enzymatic tailoring of ornithine in the biosynthesis of the Rhizobium cyclic trihydroxamate siderophore vicibactin. J Am Chem Soc 131:15317-29
Wuest, William M; Sattely, Elizabeth S; Walsh, Christopher T (2009) Three siderophores from one bacterial enzymatic assembly line. J Am Chem Soc 131:5056-7
Koglin, Alexander; Lohr, Frank; Bernhard, Frank et al. (2008) Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature 454:907-11
Calderone, Christopher T; Iwig, David F; Dorrestein, Pieter C et al. (2007) Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. Chem Biol 14:835-46
Zhou, Zhe; Lai, Jonathan R; Walsh, Christopher T (2007) Directed evolution of aryl carrier proteins in the enterobactin synthetase. Proc Natl Acad Sci U S A 104:11621-6

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