Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI053417-02
Application #
6766836
Study Section
Special Emphasis Panel (ZRG1-BM-1 (03))
Program Officer
Sizemore, Christine F
Project Start
2003-07-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$356,625
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Fay, Allison; Glickman, Michael S (2014) An essential nonredundant role for mycobacterial DnaK in native protein folding. PLoS Genet 10:e1004516
Schneider, Jessica S; Reddy, Shilpa P; E, Hock Y et al. (2013) Site-2 protease substrate specificity and coupling in trans by a PDZ-substrate adapter protein. Proc Natl Acad Sci U S A 110:19543-8
Hedhli, Dorsaf; Denis, Olivier; Barkan, Daniel et al. (2013) M.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model. PLoS One 8:e76442
Glickman, Michael S; Sawyers, Charles L (2012) Converting cancer therapies into cures: lessons from infectious diseases. Cell 148:1089-98
Barkan, Daniel; Hedhli, Dorsaf; Yan, Han-Guang et al. (2012) Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice. Infect Immun 80:1958-68
Barkan, Daniel; Stallings, Christina L; Glickman, Michael S (2011) An improved counterselectable marker system for mycobacterial recombination using galK and 2-deoxy-galactose. Gene 470:31-6
Sklar, Joseph G; Makinoshima, Hideki; Schneider, Jessica S et al. (2010) M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates. Mol Microbiol 77:605-17
Stallings, Christina L; Glickman, Michael S (2010) Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence. Microbes Infect 12:1091-101
Barkan, Daniel; Rao, Vivek; Sukenick, George D et al. (2010) Redundant function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis cyclopropanation of oxygenated mycolates. J Bacteriol 192:3661-8
Barkan, Daniel; Liu, Zhen; Sacchettini, James C et al. (2009) Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis. Chem Biol 16:499-509

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