Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI056305-02
Application #
6763065
Study Section
Special Emphasis Panel (ZRG1-BM-1 (01))
Program Officer
Deal, Carolyn D
Project Start
2003-07-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$475,692
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Deka, Ranjit K; Liu, Wei Z; Tso, Shih-Chia et al. (2018) Biophysical insights into a highly selective l-arginine-binding lipoprotein of a pathogenic treponeme. Protein Sci 27:2037-2050
Brautigam, Chad A; Deka, Ranjit K; Liu, Wei Z et al. (2017) Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum. Protein Sci 26:847-856
Radolf, Justin D; Deka, Ranjit K; Anand, Arvind et al. (2016) Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen. Nat Rev Microbiol 14:744-759
Brautigam, Chad A; Deka, Ranjit K; Liu, Wei Z et al. (2016) The Tp0684 (MglB-2) Lipoprotein of Treponema pallidum: A Glucose-Binding Protein with Divergent Topology. PLoS One 11:e0161022
Deka, Ranjit K; Brautigam, Chad A; Liu, Wei Z et al. (2016) Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm. Microbiologyopen 5:21-38
Brautigam, Chad A; Deka, Ranjit K; Liu, Wei Z et al. (2015) Insights into the potential function and membrane organization of the TP0435 (Tp17) lipoprotein from Treponema pallidum derived from structural and biophysical analyses. Protein Sci 24:11-9
Bashiri, Ghader; Baker, Edward N (2015) Production of recombinant proteins in Mycobacterium smegmatis for structural and functional studies. Protein Sci 24:1-10
Deka, Ranjit K; Brautigam, Chad A; Liu, Wei Z et al. (2015) Evidence for Posttranslational Protein Flavinylation in the Syphilis Spirochete Treponema pallidum: Structural and Biochemical Insights from the Catalytic Core of a Periplasmic Flavin-Trafficking Protein. MBio 6:e00519-15
Scheuermann, Thomas H; Brautigam, Chad A (2015) High-precision, automated integration of multiple isothermal titration calorimetric thermograms: new features of NITPIC. Methods 76:87-98
Brautigam, Chad A (2015) Fitting two- and three-site binding models to isothermal titration calorimetric data. Methods 76:124-136

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