Abstract

This research is designed to investigate nutritionally-induced alterations in hormones and the energy needs of the body. It is specifically designed to study the effects of over- and undernutrition on thyroid hormone and catecholamine metabolism, and changes in thermogenesis (energy expenditure). The nutritionally-induced alterations in hormones will be correlated with changes in thermogenesis to determine whether the changes in thermogenic hormones represent adaptive responses to altered nutrition with important survival value and whether obesity can result from a defect in adaptive thermogenesis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Project (R01)
Project #
2R01AM018535-07A1
Application #
3151146
Study Section
Endocrinology Study Section (END)
Project Start
1978-05-01
Project End
1988-06-30
Budget Start
1985-09-23
Budget End
1988-06-30
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Vermont & St Agric College
Department
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code

  Publications

Katzeff, H L; Danforth Jr, E (1989) Decreased thermic effect of a mixed meal during overnutrition in human obesity. Am J Clin Nutr 50:915-21
Acheson, K J; Ravussin, E; Schoeller, D A et al. (1988) Two-week stimulation or blockade of the sympathetic nervous system in man: influence on body weight, body composition, and twenty four-hour energy expenditure. Metabolism 37:91-8
Phinney, S D; LaGrange, B M; O'Connell, M et al. (1988) Effects of aerobic exercise on energy expenditure and nitrogen balance during very low calorie dieting. Metabolism 37:758-65
Burger, A G; O'Connell, M; Scheidegger, K et al. (1987) Monodeiodination of triiodothyronine and reverse triiodothyronine during low and high calorie diets. J Clin Endocrinol Metab 65:829-35
Sims, E A; Danforth Jr, E (1987) Expenditure and storage of energy in man. J Clin Invest 79:1019-25
Kush, R D; Young, J B; Katzeff, H L et al. (1986) Effect of diet on energy expenditure and plasma norepinephrine in lean and obese Pima Indians. Metabolism 35:1110-20
Sims, E A (1986) Energy balance in human beings: the problems of plenitude. Vitam Horm 43:1-101
Katzeff, H L; O'Connell, M; Horton, E S et al. (1986) Metabolic studies in human obesity during overnutrition and undernutrition: thermogenic and hormonal responses to norepinephrine. Metabolism 35:166-75
Katzeff, H L; Daniels, R (1985) The sympathetic nervous system in human obesity. Int J Obes 9 Suppl 2:131-7
Danforth Jr, E (1985) Diet and obesity. Am J Clin Nutr 41:1132-45