Abstract

One of the central problems in modern biology is the control of growth at the cellular level and in the whole organism. The somatomedin/insulin-like growth factor peptides are a group of hormonal peptides with strong structural homology to proinsulin. These peptides have been shown to have growth-promoting actions in many different cell types, and it is proposed that they mediate the growth-promoting actions of growth hormone on the whole body.
The specific aims of this project are to examine the pathophysiology and interrelations of the somatomedin peptides, and to study the synthesis, mode of transport in plasma, interactions with tissue receptor sites, and their biological actions. The study will utilize radioimmunoassays and radioreceptors, synthetic peptides, synthetic oligonucleotide probes, liquid chromatography, electrophoresis. The long term objectives are to clarify the role of the somatomedin peptides in growth control and to fully understand their actions. This work has health-related importance not only for disorders of human growth in childhood, but in other disease conditions where cellular growth control is disturbed such as neoplasia, diabetes, atherosclerosis and aging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Project (R01)
Project #
2R01AM024085-07
Application #
3151461
Study Section
Endocrinology Study Section (END)
Project Start
1978-12-01
Project End
1988-05-31
Budget Start
1985-06-01
Budget End
1986-05-31
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Conover, C A; Hintz, R L; Johnson, B F (1995) Differential effects of glucocorticoids on insulin-like growth factor I action in cultured human fibroblasts. J Cell Physiol 163:615-22
Conover, C A; Baker, B K; Bale, L K et al. (1993) Human hepatoma cells synthesize and secrete insulin-like growth factor Ia prohormone under growth hormone control. Regul Pept 48:1-8
Smith, R L; Palathumpat, M V; Ku, C W et al. (1989) Growth hormone stimulates insulin-like growth factor I actions on adult articular chondrocytes. J Orthop Res 7:198-207
Bennett, A E; Silverman, E D; Miller 3rd, J J et al. (1988) Insulin-like growth factors I and II in children with systemic onset juvenile arthritis. J Rheumatol 15:655-8
Conover, C A; Rosenfeld, R G; Hintz, R L (1987) Somatomedin C/insulin-like growth factor I binding and action in human fibroblasts aged in culture: impaired synergism with dexamethasone. J Gerontol 42:308-14
Conover, C A; Hintz, R L; Rosenfeld, R G (1987) Impaired synergism between somatomedin C/insulin-like growth factor I and dexamethasone in the growth of fibroblasts from a patient with insulin resistance. Pediatr Res 22:188-91
Hintz, R L (1987) Somatomedin C/insulin-like growth factor I receptors on human mononuclear cells and the IM-9 lymphoid cell line. Methods Enzymol 146:234-9
Powell, D R; Rosenfeld, R G; Sperry, J B et al. (1987) Serum concentrations of insulin-like growth factor (IGF)-1, IGF-2 and unsaturated somatomedin carrier proteins in children with chronic renal failure. Am J Kidney Dis 10:287-92
Conover, C A; Misra, P; Hintz, R L et al. (1986) Effect of an anti-insulin-like growth factor I receptor antibody on insulin-like growth factor II stimulation of DNA synthesis in human fibroblasts. Biochem Biophys Res Commun 139:501-8
Conover, C A; Rosenfeld, R G; Hintz, R L (1986) Hormonal control of the replication of human fetal fibroblasts: role of somatomedin C/insulin-like growth factor I. J Cell Physiol 128:47-54

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