Abstract

Although it is clear that both hypoinsulinemia and insulin resistance exist in patients with noninsulin dependent diabetes mellitus (NIDDM), the relationship between these two defects is not clear. Thus, there is evidence that either defect could be the primary abnormality in patients with NIDDM, the other being a secondary phenomenon. The studies proposed represent an effort to define this relationship in patients with NIDDM. The studies will consist of measuring in vivo insulin action in patients with NIDDM before, and after, control of their diabetes with insulin. If insulin replacement reduces the magnitude of the insulin resistance, it will suggest that insulin deficiency is the primary, and insulin resistance the secondary, defect in patients with NIDDM. Alternatively, persistence of insulin resistance in the presence of insulin replacement will suggest that the primary defect in NIDDM is loss of normal in vivo insulin action. The results of these experiments should provide useful information relevant to the pathogenesis of NIDDM.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Project (R01)
Project #
5R01AM030732-03
Application #
3152120
Study Section
Metabolism Study Section (MET)
Project Start
1983-01-01
Project End
1985-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Hollenbeck, C; Reaven, G M (1987) Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab 64:1169-73
Swislocki, A L; Donner, C C; Fraze, E et al. (1987) Can insulin resistance exist as a primary defect in noninsulin-dependent diabetes mellitus? J Clin Endocrinol Metab 64:778-82
Chen, Y D; Golay, A; Swislocki, A L et al. (1987) Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 64:17-21
Reaven, G M; Chen, Y D; Golay, A et al. (1987) Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 64:106-10
Hollenbeck, C B; Reaven, G M (1987) Treatment of patients with non-insulin-dependent diabetes mellitus: diabetic control and insulin secretion and action after different treatment modalities. Diabet Med 4:311-6
Hwang, I S; Ho, H; Hoffman, B B et al. (1987) Fructose-induced insulin resistance and hypertension in rats. Hypertension 10:512-6
Golay, A; Swislocki, A L; Chen, Y D et al. (1987) Relationships between plasma-free fatty acid concentration, endogenous glucose production, and fasting hyperglycemia in normal and non-insulin-dependent diabetic individuals. Metabolism 36:692-6
Reaven, G M; Chen, Y D; Moore, J G et al. (1986) Is the insulin resistance of patients with noninsulin-dependent diabetes mellitus secondary to insulin deficiency? Horm Metab Res 18:244-6
Reaven, G M; Chen, Y D; Donner, C C et al. (1985) How insulin resistant are patients with noninsulin-dependent diabetes mellitus? J Clin Endocrinol Metab 61:32-6
Donner, C C; Fraze, E; Chen, Y D et al. (1985) Quantitation of insulin-stimulated glucose disposal in patients with non-insulin-dependent diabetes mellitus. Diabetes 34:831-5

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