Abstract

The investigator proposes to continue study of the factors which regulate transport and urinary excretion of magnesium and the role of calcium in hormonal action. Microperfusion of isolated tubular segments will be utilized to determine mechanisms of transport and the effects of diet and hormones. Studies will be continued using electron probe microanalysis and NMR to characterize intracelluar phosphate concentrations and the relationship between this and the cellular effects of parathyroid hormone.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Project (R01)
Project #
5R01AM033138-36
Application #
3152720
Study Section
(SSS)
Project Start
1983-12-01
Project End
1986-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
36
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Ziyadeh, F N; Kelepouris, E; Agus, Z S (1988) Benzodiazepines stimulate sodium ion transport in frog skin epithelium. Biochim Biophys Acta 940:93-8
Ziyadeh, F N; Agus, Z S (1988) Benzodiazepines inhibit transport-related oxygen consumption in thick ascending limb. Am J Physiol 255:C385-92
Ziyadeh, F N; Kelepouris, E; Agus, Z S (1987) Thiazides stimulate calcium absorption in urinary bladder of winter flounder. Biochim Biophys Acta 897:52-6
Ziyadeh, F N; Kelepouris, E; Agus, Z S (1986) Relationships between calcium and chloride transport in frog skin glands. Am J Physiol 251:F647-54
Kelepouris, E; Agus, Z S; Civan, M M (1985) Intracellular calcium activity in split frog skin epithelium: effect of cAMP. J Membr Biol 88:113-21
Ziyadeh, F N; Kelepouris, E; Civan, M M et al. (1985) cAMP- and beta-adrenergic-stimulated chloride-dependent Ca2+ secretion in frog skin. Am J Physiol 249:F713-22