Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR010493-35
Application #
6652675
Study Section
Special Emphasis Panel (ZRG1-BM-2 (09))
Program Officer
Gretz, Elizabeth
Project Start
1977-06-01
Project End
2005-08-31
Budget Start
2003-09-01
Budget End
2005-08-31
Support Year
35
Fiscal Year
2003
Total Cost
$417,416
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Malawista, Stephen E; de Boisfleury Chevance, Anne (2008) Clocking the Lyme spirochete. PLoS One 3:e1633
Malawista, Stephen E; de Boisfleury Chevance, Anne; van Damme, Jo et al. (2008) Tonic inhibition of chemotaxis in human plasma. Proc Natl Acad Sci U S A 105:17949-54
Montgomery, Ruth R; Booth, Carmen J; Wang, Xiaomei et al. (2007) Recruitment of macrophages and polymorphonuclear leukocytes in L:yme carditis. Infect Immun 75:613-20
Malawista, Stephen E; de Boisfleury Chevance, Anne (2007) Phagocytic function of human blood polymorphonuclear leukocytes in the presence of carrageenan, a potential vaginal microbicide. Inflammation 30:131-5
Malawista, Stephen E; Smith, Eileen O; Seibyl, John P (2006) Cryopreservable neutrophil surrogates: granule-poor, motile cytoplasts from polymorphonuclear leukocytes home to inflammatory lesions in vivo. Cell Motil Cytoskeleton 63:254-7
Montgomery, Ruth R; Schreck, Kimberly; Wang, Xiaomei et al. (2006) Human neutrophil calprotectin reduces the susceptibility of Borrelia burgdorferi to penicillin. Infect Immun 74:2468-72
Montgomery, Ruth R; Lusitani, Denise; De Boisfleury Chevance, Anne et al. (2004) Tick saliva reduces adherence and area of human neutrophils. Infect Immun 72:2989-94
Liu, Nengyin; Montgomery, Ruth R; Barthold, Stephen W et al. (2004) Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected mice. Infect Immun 72:3195-203
Lusitani, Denise; Malawista, Stephen E; Montgomery, Ruth R (2003) Calprotectin, an abundant cytosolic protein from human polymorphonuclear leukocytes, inhibits the growth of Borrelia burgdorferi. Infect Immun 71:4711-6
Lusitani, Denise; Malawista, Stephen E; Montgomery, Ruth R (2002) Borrelia burgdorferi are susceptible to killing by a variety of human polymorphonuclear leukocyte components. J Infect Dis 185:797-804

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