Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
2R01AR011262-27A3
Application #
2078278
Study Section
General Medicine B Study Section (GMB)
Project Start
1978-07-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
27
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Pharmacology
Type
Schools of Dentistry
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Wang, J; Stern, P H (2011) Dose-dependent differential effects of risedronate on gene expression in osteoblasts. Biochem Pharmacol 81:1036-42
Wang, J; Gilchrist, A; Stern, P H (2011) Antagonist minigenes identify genes regulated by parathyroid hormone through G protein-selective and G protein co-regulated mechanisms in osteoblastic cells. Cell Signal 23:380-8
Wang, Jun; Stern, Paula H (2010) Osteoclastogenic activity and RANKL expression are inhibited in osteoblastic cells expressing constitutively active G?(12) or constitutively active RhoA. J Cell Biochem 111:1531-6
Yoshida, Tomohiko; Clark, Mary F; Stern, Paula H (2009) The small GTPase RhoA is crucial for MC3T3-E1 osteoblastic cell survival. J Cell Biochem 106:896-902
Kazmers, Nikolas H; Ma, Sophia A; Yoshida, Tomohiko et al. (2009) Rho GTPase signaling and PTH 3-34, but not PTH 1-34, maintain the actin cytoskeleton and antagonize bisphosphonate effects in mouse osteoblastic MC3T3-E1 cells. Bone 45:52-60
Singh, A T K; Gilchrist, A; Voyno-Yasenetskaya, T et al. (2005) G alpha12/G alpha13 subunits of heterotrimeric G proteins mediate parathyroid hormone activation of phospholipase D in UMR-106 osteoblastic cells. Endocrinology 146:2171-5
Dossing, Debra A; Stern, Paula H (2005) Receptor activator of NF-kappaB ligand protein expression in UMR-106 cells is differentially regulated by parathyroid hormone and calcitriol. J Cell Biochem 95:1029-41
Singh, Amareshwar T K; Frohman, Michael A; Stern, Paula H (2005) Parathyroid hormone stimulates phosphatidylethanolamine hydrolysis by phospholipase D in osteoblastic cells. Lipids 40:1135-40
Radeff, Julie M; Nagy, Zsolt; Stern, Paula H (2004) Rho and Rho kinase are involved in parathyroid hormone-stimulated protein kinase C alpha translocation and IL-6 promoter activity in osteoblastic cells. J Bone Miner Res 19:1882-91
Radeff, Julie M; Singh, Amareshwar T K; Stern, Paula H (2004) Role of protein kinase A, phospholipase C and phospholipase D in parathyroid hormone receptor regulation of protein kinase Calpha and interleukin-6 in UMR-106 osteoblastic cells. Cell Signal 16:105-14

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