Abstract

The overall objective of this proposal is to elucidate the pathogenic mechanisms of cartilage damage in human arthritis. It is proposed to study 1) the interactions of cartilage chondrocytes with anti-collagen antibodies present in a proportion of synovial fluids of patients with rheumatoid arthritis, and their effects on chondrocyte function; 2) the role of oxidative processes mediated by inflammatory cells in synovial fluids on the generation of noxious lipids peroxides and modified immunoglobulins, and their effects on chondrocytes, polymorphonuclear leukocytes and monocytes. These studies will involve the use of a variety of biochemical and immunochemical techniques.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
2R01AR016209-19A1
Application #
3154878
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1991-09-30
Project End
1997-01-31
Budget Start
1993-02-01
Budget End
1994-01-31
Support Year
19
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of Arkansas for Medical Sciences
Department
Type
Schools of Medicine
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205

  Publications

Mitani, Y; Honda, A; Jasin, H E (2001) Polymorphonuclear leukocyte adhesion to articular cartilage is inhibited by cartilage surface macromolecules. Rheumatol Int 20:180-5
Jasin, H E (2000) Mechanisms of joint destruction in rheumatoid arthritis. J Orthop Sci 5:178-81
Uesugi, M; Yoshida, K; Jasin, H E (2000) Inflammatory properties of IgG modified by oxygen radicals and peroxynitrite. J Immunol 165:6532-7
Noyori, K; Takagi, T; Jasin, H E (1998) Characterization of the macromolecular components of the articular cartilage surface. Rheumatol Int 18:71-7
Uesugi, M; Hayashi, T; Jasin, H E (1998) Covalent cross-linking of immune complexes by oxygen radicals and nitrite. J Immunol 161:1422-7
Hayashi, T; Abe, E; Yamate, T et al. (1997) Nitric oxide production by superficial and deep articular chondrocytes. Arthritis Rheum 40:261-9
Jasin, H E (1995) Structure and function of the articular cartilage surface. Scand J Rheumatol Suppl 101:51-5
Noyori, K; Koshino, T; Takagi, T et al. (1994) Binding characteristics of antitype II collagen antibody to the surface of diseased human cartilage as a probe for tissue damage. J Rheumatol 21:293-6
Jasin, H E (1994) The articular cartilage surface as a target organ. Clin Exp Rheumatol 12:469-72
Noyori, K; Jasin, H E (1994) Repair characteristics of the articular cartilage surface following acute inflammatory arthritis. J Rheumatol 21:1731-3

Showing the most recent 10 out of 18 publications