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Gangopadhyay, Jaya P; Ikemoto, Noriaki (2008) Interaction of the Lys(3614)-Asn(3643) calmodulin-binding domain with the Cys(4114)-Asn(4142) region of the type 1 ryanodine receptor is involved in the mechanism of Ca2+/agonist-induced channel activation. Biochem J 411:415-23
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Laver, Derek R; Hamada, Tomoyo; Fessenden, James D et al. (2007) The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca(2+) binding site. J Membr Biol 220:11-20
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Bannister, Mark L; Hamada, Tomoyo; Murayama, Takashi et al. (2007) Malignant hyperthermia mutation sites in the Leu2442-Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area. Biochem J 401:333-9
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Hamada, Tomoyo; Bannister, Mark L; Ikemoto, Noriaki (2007) Peptide probe study of the role of interaction between the cytoplasmic and transmembrane domains of the ryanodine receptor in the channel regulation mechanism. Biochemistry 46:4272-9
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Murayama, Takashi; Oba, Toshiharu; Hara, Hiroshi et al. (2007) Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia. Biochem J 402:349-57
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Gangopadhyay, Jaya Pal; Ikemoto, Noriaki (2006) Role of the Met3534-Ala4271 region of the ryanodine receptor in the regulation of Ca2+ release induced by calmodulin binding domain peptide. Biophys J 90:2015-26
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Bannister, Mark L; Ikemoto, Noriaki (2006) Effects of peptide C corresponding to the Glu724-Pro760 region of the II-III loop of the DHP (dihydropyridine) receptor alpha1 subunit on the domain- switch-mediated activation of RyR1 (ryanodine receptor 1) Ca2+ channels. Biochem J 394:145-52
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Yang, Zhaokang; Ikemoto, Noriaki; Lamb, Graham D et al. (2006) The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes. Cardiovasc Res 70:475-85
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Kobayashi, Shigeki; Bannister, Mark L; Gangopadhyay, Jaya P et al. (2005) Dantrolene stabilizes domain interactions within the ryanodine receptor. J Biol Chem 280:6580-7
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Murayama, Takashi; Oba, Toshiharu; Kobayashi, Shigeki et al. (2005) Postulated role of interdomain interactions within the type 1 ryanodine receptor in the low gain of Ca2+-induced Ca2+ release activity of mammalian skeletal muscle sarcoplasmic reticulum. Am J Physiol Cell Physiol 288:C1222-30
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