Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR028304-13
Application #
2078643
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1981-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Yeowell, H N; Marshall, M K; Walker, L C et al. (1994) Regulation of lysyl oxidase mRNA in dermal fibroblasts from normal donors and patients with inherited connective tissue disorders. Arch Biochem Biophys 308:299-305
Murad, S; Walker, L C; Tajima, S et al. (1994) Minimum structural requirements for minoxidil inhibition of lysyl hydroxylase in cultured fibroblasts. Arch Biochem Biophys 308:42-7
Phillips, C L; Combs, S B; Pinnell, S R (1994) Effects of ascorbic acid on proliferation and collagen synthesis in relation to the donor age of human dermal fibroblasts. J Invest Dermatol 103:228-32
Handa, J T; Murad, S; Jaffe, G J (1993) Minoxidil inhibits ocular cell proliferation and lysyl hydroxylase activity. Invest Ophthalmol Vis Sci 34:567-75
Halperin, E C; Gaspar, L; George, S et al. (1993) A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. CNS Cancer Consortium. Int J Radiat Oncol Biol Phys 26:413-6
Darr, D; Combs, S; Dunston, S et al. (1992) Topical vitamin C protects porcine skin from ultraviolet radiation-induced damage. Br J Dermatol 127:247-53
Yeowell, H N; Ha, V; Walker, L C et al. (1992) Characterization of a partial cDNA for lysyl hydroxylase from human skin fibroblasts;lysyl hydroxylase mRNAs are regulated differently by minoxidil derivatives and hydralazine. J Invest Dermatol 99:864-9
Phillips, C L; Tajima, S; Pinnell, S R (1992) Ascorbic acid and transforming growth factor-beta 1 increase collagen biosynthesis via different mechanisms: coordinate regulation of pro alpha 1(I) and Pro alpha 1(III) collagens. Arch Biochem Biophys 295:397-403
Murad, S; Tennant, M C; Pinnell, S R (1992) Structure-activity relationship of minoxidil analogs as inhibitors of lysyl hydroxylase in cultured fibroblasts. Arch Biochem Biophys 292:234-8
Phillips, C L; Lever, L W; Pinnell, S R et al. (1991) Construction of a full-length murine pro alpha 2(I) collagen cDNA by the polymerase chain reaction. J Invest Dermatol 97:980-4

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