Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR033962-12
Application #
2078953
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1983-09-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Hahn, B H; Singh, R R; Wong, W K et al. (2001) Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus. Arthritis Rheum 44:432-41
Hahn, B H; Singh, R R; Ebling, F M (1998) Self Ig peptides that help anti-DNA antibody production: importance of charged residues. Lupus 7:307-13
Hahn, B H (1998) Antibodies to DNA. N Engl J Med 338:1359-68
Song, Y W; Han, C W; Kang, S W et al. (1998) Abnormal distribution of Fc gamma receptor type IIa polymorphisms in Korean patients with systemic lupus erythematosus. Arthritis Rheum 41:421-6
Hahn, B H (1997) The potential role of autologous stem cell transplantation in patients with systemic lupus erythematosus. J Rheumatol Suppl 48:89-93
Tsao, B P; Cantor, R M; Kalunian, K C et al. (1997) Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus. J Clin Invest 99:725-31
Hahn, B H; Singh, R R; Tsao, B P et al. (1997) Peptides from Vh regions of antibodies to DNA activate T cell help to upregulate autoantibody synthesis. Lupus 6:330-2
Singh, R R; Hahn, B H; Sercarz, E E (1996) Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity. J Exp Med 183:1613-21
Singh, R R; Ebling, F M; Sercarz, E E et al. (1995) Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus. J Clin Invest 96:2990-6
Singh, R R; Kumar, V; Ebling, F M et al. (1995) T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus. J Exp Med 181:2017-27

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