Regulation of Gene Expression in Cartilage

Sandell, Linda J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Research Project (R01)
• Project #: 5R01AR036994-10
• Application #: 2079182
• Study Section: Pathobiochemistry Study Section (PBC)
• Project Start: 1987-01-01
• Project End: 2000-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 10
• Fiscal Year: 1996

Institution

• Name: University of Washington
• Department: Orthopedics
• Type: Schools of Medicine
• DUNS #: 135646524
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98195

Publications

Zhang, Ziji; Zhang, Zhiqi; Kang, Yan et al. (2014) Resistin stimulates expression of chemokine genes in chondrocytes via combinatorial regulation of C/EBP? and NF-?B. Int J Mol Sci 15:17242-55

Rai, M F; Sandell, L J; Cheverud, J M et al. (2013) Relationship of age and body mass index to the expression of obesity and osteoarthritis-related genes in human meniscus. Int J Obes (Lond) 37:1238-46

Patra, Debabrata; Sandell, Linda J (2011) Recent advances in biomarkers in osteoarthritis. Curr Opin Rheumatol 23:465-70

Hayashi, Shinya; Wang, Zhepeng; Bryan, Jennifer et al. (2011) The type II collagen N-propeptide, PIIBNP, inhibits cell survival and bone resorption of osteoclasts via integrin-mediated signaling. Bone 49:644-52

Zhang, Zhiqi; Xing, Xiaoyun; Hensley, Gretchen et al. (2010) Resistin induces expression of proinflammatory cytokines and chemokines in human articular chondrocytes via transcription and messenger RNA stabilization. Arthritis Rheum 62:1993-2003

Wang, Zhepeng; Bryan, Jennifer; Franz, Carl et al. (2010) Type IIB procollagen NH(2)-propeptide induces death of tumor cells via interaction with integrins alpha(V)beta(3) and alpha(V)beta(5). J Biol Chem 285:20806-17

Zhang, Zhiqi; Bryan, Jennifer L; DeLassus, Elizabeth et al. (2010) CCAAT/enhancer-binding protein ? and NF-?B mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1?. J Biol Chem 285:33092-103

Schmid, Gregory J; Kobayashi, Chikashi; Sandell, Linda J et al. (2009) Fibroblast growth factor expression during skeletal fracture healing in mice. Dev Dyn 238:766-74

Rich, Jason T; Rosova, Ivana; Nolta, Jan A et al. (2008) Upregulation of Runx2 and Osterix during in vitro chondrogenesis of human adipose-derived stromal cells. Biochem Biophys Res Commun 372:230-5

Sandell, L J; Xing, X; Franz, C et al. (2008) Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta. Osteoarthritis Cartilage 16:1560-71