The goal of the proposed research is to better understand the mechanical factors in surgical repair procedures for chronic anterolateral insufficiency of the knee, for which the repair requires an anterior cruciate substitute to be established. Experiments will be run on cadaver knee specimens in which ligament forces will by measured by buckle force transducers on the four major knee ligaments, and a six degree-of-freedom goniometer system will be used to measure 3-dimensional knee motion, when the knee is subjected to a wide variety of external load directions. Normal knees, knees with a simulated anterolateral injury, and knees repaired by one of eight procedures will be tested in an identical manner. Theoretical ligament lengths, and hence, loaded ligament states, will be predicted using already developed theoretical knee models, with the measured 3-D motion as input. The influence of repair insertion location will be studied both theoretically and experimentally. The normal and repaired knees will be compared on the basis of anterior cruciate or substitute force magnitude, joint laxity, and load sharing by the other ligaments.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR038398-04
Application #
3158538
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1986-07-01
Project End
1991-02-28
Budget Start
1989-07-01
Budget End
1991-02-28
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
LaPrade, Robert F; Muench, Carter; Wentorf, Fred et al. (2002) The effect of injury to the posterolateral structures of the knee on force in a posterior cruciate ligament graft: a biomechanical study. Am J Sports Med 30:233-8
Wentorf, Fred A; LaPrade, Robert F; Lewis, Jack L et al. (2002) The influence of the integrity of posterolateral structures on tibiofemoral orientation when an anterior cruciate ligament graft is tensioned. Am J Sports Med 30:796-9
Lundberg, W R; Lewis, J L; Smith, J J et al. (1997) In vivo forces during remodeling of a two-segment anterior cruciate ligament graft in a goat model. J Orthop Res 15:645-51
Smith, J J; Lewis, J L; Mente, P L et al. (1996) Intraoperative force-setting did not improve the mechanical properties of an augmented bone-tendon-bone anterior cruciate ligament graft in a goat model. J Orthop Res 14:209-15
Lewis, J L; Poff, B C; Smith, J J et al. (1994) Method for establishing and measuring in vivo forces in an anterior cruciate ligament composite graft: response to differing levels of load sharing in a goat model. J Orthop Res 12:780-8
Muneta, T; Lewis, J L; Stewart, N J (1994) Load affects remodeling of transplanted, autogenous bone-patellar tendon-bone segments in a rabbit model. J Orthop Res 12:138-43
Gertel, T H; Lew, W D; Lewis, J L et al. (1993) Effect of anterior cruciate ligament graft tensioning direction, magnitude, and flexion angle on knee biomechanics. Am J Sports Med 21:572-81
Stewart, N J; Engebretsen, L; Lewis, J L et al. (1993) Maintenance of set force in anterior cruciate ligament grafts. J Orthop Res 11:149-53
Kirstukas, S J; Lewis, J L; Erdman, A G (1992) 6R instrumented spatial linkages for anatomical joint motion measurement--Part 1: Design. J Biomech Eng 114:92-100
Kirstukas, S J; Lewis, J L; Erdman, A G (1992) 6R instrumented spatial linkages for anatomical joint motion measurement--Part 2: Calibration. J Biomech Eng 114:101-10

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