Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
3R01AR038917-08S1
Application #
2599475
Study Section
Biochemistry Study Section (BIO)
Project Start
1988-04-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
8
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Ohio State University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Xia, M; Dempski, R; Hille, R (1999) The reductive half-reaction of xanthine oxidase. Reaction with aldehyde substrates and identification of the catalytically labile oxygen. J Biol Chem 274:3323-30
Conrads, T; Hemann, C; Hille, R (1998) Formation of a tyrosyl radical in xanthine oxidase. Biochemistry 37:7787-91
Michaud, A L; Herrick, J A; Duplain, J E et al. (1998) FTIR characterization of heterocycles lumazine and violapterin in solution: effects of solvent on anionic forms. Biospectroscopy 4:235-56
Kim, J H; Ryan, M G; Knaut, H et al. (1996) The reductive half-reaction of xanthine oxidase. The involvement of prototropic equilibria in the course of the catalytic sequence. J Biol Chem 271:6771-80
Sun, J; Kahlow, M A; Kaysser, T M et al. (1996) Resonance Raman spectroscopic identification of a histidine ligand of b595 and the nature of the ligation of chlorin d in the fully reduced Escherichia coli cytochrome bd oxidase. Biochemistry 35:2403-12
Brody, M S; Hille, R (1995) The reaction of chicken liver sulfite oxidase with dimethylsulfite. Biochim Biophys Acta 1253:133-5
Hille, R; Nishino, T (1995) Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase. FASEB J 9:995-1003
Hille, R (1994) The reaction mechanism of oxomolybdenum enzymes. Biochim Biophys Acta 1184:143-69
Lorigan, G A; Britt, R D; Kim, J H et al. (1994) Electron spin echo envelope modulation spectroscopy of the molybdenum center of xanthine oxidase. Biochim Biophys Acta 1185:284-94
Ratnam, K; Hille, R (1993) Paradoxical stabilization of the neutral flavin semiquinone of xanthine dehydrogenase at high pH. Biochem Biophys Res Commun 194:1097-102

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