Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR038945-08
Application #
2079401
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1987-08-01
Project End
1998-04-30
Budget Start
1996-07-01
Budget End
1998-04-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Rochester
Department
Orthopedics
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Zhang, Yongchun; Sheu, Tzong-jen; Hoak, Donna et al. (2016) CCN1 Regulates Chondrocyte Maturation and Cartilage Development. J Bone Miner Res 31:549-59
Dao, Debbie Y; Jonason, Jennifer H; Zhang, Yongchun et al. (2012) Cartilage-specific ?-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. J Bone Miner Res 27:1680-94
Gunnell, Lea M; Jonason, Jennifer H; Loiselle, Alayna E et al. (2010) TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. J Bone Miner Res 25:1784-97
Wu, Qiuqian; Kim, Kyung-Ok; Sampson, Erik R et al. (2008) Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. Arthritis Rheum 58:3132-44
Li, Tian-Fang; Darowish, Michael; Zuscik, Michael J et al. (2006) Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. J Bone Miner Res 21:4-16
Li, Tian-Fang; O'Keefe, Regis J; Chen, Di (2005) TGF-beta signaling in chondrocytes. Front Biosci 10:681-8
Li, Tian-Fang; Zuscik, Michael J; Ionescu, Andreia M et al. (2004) PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling. Exp Cell Res 300:159-69
Li, Xuefeng; Schwarz, Edward M; Zuscik, Michael J et al. (2003) Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5. Endocrinology 144:2514-23
Zhang, Donghui; Ferguson, Cristin M; O'Keefe, Regis J et al. (2002) A role for the BMP antagonist chordin in endochondral ossification. J Bone Miner Res 17:293-300
Ionescu, A M; Schwarz, E M; Vinson, C et al. (2001) PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling. J Biol Chem 276:11639-47

Showing the most recent 10 out of 14 publications