Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR039555-10
Application #
2079571
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1988-09-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Kono, Dwight H; Baccala, Roberto; Theofilopoulos, Argyrios N (2013) TLRs and interferons: a central paradigm in autoimmunity. Curr Opin Immunol 25:720-7
Baccala, Roberto; Gonzalez-Quintial, Rosana; Blasius, Amanda L et al. (2013) Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci U S A 110:2940-5
Koh, Yi Ting; Scatizzi, John C; Gahan, Jennifer D et al. (2013) Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells. J Immunol 190:4982-90
Lawson, Brian R; Eleftheriadis, Theodoros; Tardif, Virginie et al. (2012) Transmethylation in immunity and autoimmunity. Clin Immunol 143:8-21
Scatizzi, John C; Haraldsson, Maria K; Pollard, K Michael et al. (2012) The Lbw2 locus promotes autoimmune hemolytic anemia. J Immunol 188:3307-14
Theofilopoulos, Argyrios N; Kono, Dwight H; Beutler, Bruce et al. (2011) Intracellular nucleic acid sensors and autoimmunity. J Interferon Cytokine Res 31:867-86
Theofilopoulos, Argyrios N; Gonzalez-Quintial, Rosana; Lawson, Brian R et al. (2010) Sensors of the innate immune system: their link to rheumatic diseases. Nat Rev Rheumatol 6:146-56
Aït-Azzouzene, Djemel; Kono, Dwight H; Gonzalez-Quintial, Rosana et al. (2010) Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice. J Immunol 185:1015-27
Wickramarachchi, Dilki C; Theofilopoulos, Argyrios N; Kono, Dwight H (2010) Immune pathology associated with altered actin cytoskeleton regulation. Autoimmunity 43:64-75
Kono, Dwight H; Haraldsson, M Katarina; Lawson, Brian R et al. (2009) Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proc Natl Acad Sci U S A 106:12061-6

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