Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR039875-07
Application #
2079751
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1991-03-01
Project End
1997-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Khare, S D; Lee, S; Bull, M J et al. (2001) Spontaneous inflammatory disease in HLA-B27 transgenic mice does not require transporter of antigenic peptides. Clin Immunol 98:364-9
Lee, S; Khare, S D; Griffiths, M M et al. (2000) HLA-B27 transgenic mice are susceptible to collagen-induced arthritis: type II collagen as a potential target in human disease. Hum Immunol 61:140-7
Khare, S D; Lee, S; Bull, M J et al. (1999) Peptide binding alpha1alpha2 domain of HLA-B27 contributes to the disease pathogenesis in transgenic mice. Hum Immunol 60:116-26
Khare, S D; Bull, M J; Hanson, J et al. (1998) Spontaneous inflammatory disease in HLA-B27 transgenic mice is independent of MHC class II molecules: a direct role for B27 heavy chains and not B27-derived peptides. J Immunol 160:101-6
Khare, S D; Luthra, H S; David, C S (1998) Animal models of human leukocyte antigen B27-linked arthritides. Rheum Dis Clin North Am 24:883-94, xi-xii
Khare, S D; Luthra, H S; David, C S (1998) Unraveling the mystery of HLA-B27 association with human spondyloarthropathies using transgenic and knock out mice. Semin Immunol 10:15-23
Khare, S D; Luthra, H S; David, C S (1996) Role of HLA-B27 in spondyloarthropathies. Curr Top Microbiol Immunol 206:85-100
Khare, S D; Hansen, J; Luthra, H S et al. (1996) HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human beta2-microglobulin (beta2m) double transgenic mice with disrupted mouse beta2m. J Clin Invest 98:2746-55
Khare, S D; Luthra, H S; David, C S (1995) Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies. J Exp Med 182:1153-8
Pedrinaci, S; Hanson, J; David, C (1994) Hierarchy in the assembly of HLA-B27 and HLA-Cw3 molecules in transgenic mice. Immunogenetics 39:130-7

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