Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
3R01AR042525-02S1
Application #
2081847
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1993-09-30
Project End
1998-08-31
Budget Start
1994-09-01
Budget End
1995-08-31
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Richardson, Bruce (2018) The interaction between environmental triggers and epigenetics in autoimmunity. Clin Immunol 192:1-5
Strickland, Faith M; Patel, Dipak; Khanna, Dinesh et al. (2016) Characterisation of an epigenetically altered CD4(+) CD28(+) Kir(+) T cell subset in autoimmune rheumatic diseases by multiparameter flow cytometry. Lupus Sci Med 3:e000147
Strickland, Faith M; Li, YePeng; Johnson, Kent et al. (2015) CD4(+) T cells epigenetically modified by oxidative stress cause lupus-like autoimmunity in mice. J Autoimmun 62:75-80
Gorelik, Gabriela; Sawalha, Amr H; Patel, Dipak et al. (2015) T cell PKC? kinase inactivation induces lupus-like autoimmunity in mice. Clin Immunol 158:193-203
Li, YePeng; Gorelik, Gabriela; Strickland, Faith M et al. (2014) Oxidative stress, T cell DNA methylation, and lupus. Arthritis Rheumatol 66:1574-82
Somers, E C; Richardson, B C (2014) Environmental exposures, epigenetic changes and the risk of lupus. Lupus 23:568-76
Richardson, Bruce C; Patel, Dipak R (2014) Epigenetics in 2013. DNA methylation and miRNA: key roles in systemic autoimmunity. Nat Rev Rheumatol 10:72-4
Strickland, Faith M; Hewagama, Anura; Wu, Ailing et al. (2013) Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus. Arthritis Rheum 65:1872-81
Hewagama, Anura; Gorelik, Gabriela; Patel, Dipak et al. (2013) Overexpression of X-linked genes in T cells from women with lupus. J Autoimmun 41:60-71
Hughes, Travis; Adler, Adam; Merrill, Joan T et al. (2012) Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann Rheum Dis 71:694-9

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