Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR042703-03
Application #
2082131
Study Section
Physiology Study Section (PHY)
Project Start
1994-03-10
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Cannon, Stephen C (2017) An atypical CaV1.1 mutation reveals a common mechanism for hypokalemic periodic paralysis. J Gen Physiol 149:1061-1064
Cannon, Stephen C (2017) Mind the magnesium, in dantrolene suppression of malignant hyperthermia. Proc Natl Acad Sci U S A 114:4576-4578
Cannon, Stephen C (2015) Channelopathies of skeletal muscle excitability. Compr Physiol 5:761-90
Wu, Fenfen; Mi, Wentao; Cannon, Stephen C (2013) Bumetanide prevents transient decreases in muscle force in murine hypokalemic periodic paralysis. Neurology 80:1110-6
Wu, Fenfen; Mi, Wentao; Hernández-Ochoa, Erick O et al. (2012) A calcium channel mutant mouse model of hypokalemic periodic paralysis. J Clin Invest 122:4580-91
Wu, Fenfen; Mi, Wentao; Burns, Dennis K et al. (2011) A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis. J Clin Invest 121:4082-94
Fu, Yu; Struyk, Arie; Markin, Vladislav et al. (2011) Gating behaviour of sodium currents in adult mouse muscle recorded with an improved two-electrode voltage clamp. J Physiol 589:525-46
Francis, David G; Rybalchenko, Volodymyr; Struyk, Arie et al. (2011) Leaky sodium channels from voltage sensor mutations in periodic paralysis, but not paramyotonia. Neurology 76:1635-41
Cannon, Stephen C (2010) Voltage-sensor mutations in channelopathies of skeletal muscle. J Physiol 588:1887-95
Webb, Jadon; Wu, Fen-fen; Cannon, Stephen C (2009) Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit. Pflugers Arch 457:1253-63

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